The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease
BACKGROUND Chronic kidney disease (CKD) is an increasing burden on individuals and on the healthcare system. The need to identify more sensitive and specific markers of CKD cannot be overemphasized to facilitate detection and appropriate intervention. β2 microglobulin is one of such markers of CKD...
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Faculty of Medicine Trisakti University
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doaj-88c26678ac3e4321918e6c49c93fbb882021-08-15T06:22:12ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302019-11-0138310.18051/UnivMed.2019.v38.172-178387The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney diseaseAugustine Onovuakpo Eguvbe0Marcellinus Uchechukwu Nwagu1Eshiotseme Sylvester Idogun2Adeyinka Abdulrasaq Akande3Edo University, IyamhoEdo University, Iyamho, Edo StateUniversity of Benin, Benin City, Edo State.University of Ilorin, Ilorin. BACKGROUND Chronic kidney disease (CKD) is an increasing burden on individuals and on the healthcare system. The need to identify more sensitive and specific markers of CKD cannot be overemphasized to facilitate detection and appropriate intervention. β2 microglobulin is one of such markers of CKD. The aim of this study was to investigate the sensitivities and specificities of serum β2 microglobulin and major biochemical markers of CKD, namely creatinine and urine albumin. METHODS This was a hospital-based cross-sectional study involving 124 subjects with CKD and 124 healthy controls. Participants were categorized in two groups : group 1 the CKD based on persistent reduction in GFR <60 mL/min/1.73 m2 and group 2 healthy subjects as controls. Blood (serum) samples of participants were analyzed for serum creatinine and serum β2 microglobulin while their urine samples were analyzed for creatinine and albumin. Urine albumin creatinine ratio (UACR) was calculated from the results of the analyses. RESULTS There was a very strong positive correlation of serum β2 microglobulin with serum creatinine (r=0.750; p=0.000) and UACR (r=0.775; p=0.000), respectively. Also, there was a very strong negative correlation between serum β2 microglobulin and eGFR (r=-0.866; p=0.000). UACR had the highest sensitivity and specificity as shown by receiver operating curve characteristics (ROC) analysis. CONCLUSION In CKD, UACR and serum β2 microglobulin had the best diagnostic value. Periodic renal assessment of renal patients is mandatory as they may be affected by hidden renal dysfunction. https://univmed.org/ejurnal/index.php/medicina/article/view/880β2 microglobulinserum creatinineurine albumin creatinine ratiochronic kidney disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Augustine Onovuakpo Eguvbe Marcellinus Uchechukwu Nwagu Eshiotseme Sylvester Idogun Adeyinka Abdulrasaq Akande |
spellingShingle |
Augustine Onovuakpo Eguvbe Marcellinus Uchechukwu Nwagu Eshiotseme Sylvester Idogun Adeyinka Abdulrasaq Akande The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease Universa Medicina β2 microglobulin serum creatinine urine albumin creatinine ratio chronic kidney disease |
author_facet |
Augustine Onovuakpo Eguvbe Marcellinus Uchechukwu Nwagu Eshiotseme Sylvester Idogun Adeyinka Abdulrasaq Akande |
author_sort |
Augustine Onovuakpo Eguvbe |
title |
The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
title_short |
The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
title_full |
The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
title_fullStr |
The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
title_full_unstemmed |
The role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
title_sort |
role of urine albumin creatinine ratio and serum β2 microglobulin as biomarkers of chronic kidney disease |
publisher |
Faculty of Medicine Trisakti University |
series |
Universa Medicina |
issn |
1907-3062 2407-2230 |
publishDate |
2019-11-01 |
description |
BACKGROUND
Chronic kidney disease (CKD) is an increasing burden on individuals and on the healthcare system. The need to identify more sensitive and specific markers of CKD cannot be overemphasized to facilitate detection and appropriate intervention. β2 microglobulin is one of such markers of CKD. The aim of this study was to investigate the sensitivities and specificities of serum β2 microglobulin and major biochemical markers of CKD, namely creatinine and urine albumin.
METHODS
This was a hospital-based cross-sectional study involving 124 subjects with CKD and 124 healthy controls. Participants were categorized in two groups : group 1 the CKD based on persistent reduction in GFR <60 mL/min/1.73 m2 and group 2 healthy subjects as controls. Blood (serum) samples of participants were analyzed for serum creatinine and serum β2 microglobulin while their urine samples were analyzed for creatinine and albumin. Urine albumin creatinine ratio (UACR) was calculated from the results of the analyses.
RESULTS
There was a very strong positive correlation of serum β2 microglobulin with serum creatinine (r=0.750; p=0.000) and UACR (r=0.775; p=0.000), respectively. Also, there was a very strong negative correlation between serum β2 microglobulin and eGFR (r=-0.866; p=0.000). UACR had the highest sensitivity and specificity as shown by receiver operating curve characteristics (ROC) analysis.
CONCLUSION
In CKD, UACR and serum β2 microglobulin had the best diagnostic value. Periodic renal assessment of renal patients is mandatory as they may be affected by hidden renal dysfunction.
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topic |
β2 microglobulin serum creatinine urine albumin creatinine ratio chronic kidney disease |
url |
https://univmed.org/ejurnal/index.php/medicina/article/view/880 |
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