Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem
Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterin...
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doaj-88cc5f1776a54d68910e918b6a8b713e2020-11-29T00:00:42ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-0193870387010.3390/jcm9123870Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic ProblemKrzysztof Jabłoński0Łukasz Kurek1Maciej Żukowski2Natalia Data-Jabłońska3Karolina Żukowska4Anna J. Milewska5Aleksandra Lipka6Marcin Jóźwik7Clinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, PolandClinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, PolandClinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, PolandClinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, PolandDepartment of Oncology and Immunooncology, Hospital Ministry of the Interior and Administration with Warmia and Mazury Oncology Center, Olsztyn, Wojska Polskiego Ave. 37, 10-228 Olsztyn, PolandDepartment of Statistics and Medical Informatics, Medical University of Białystok, Białystok, Szpitalna Str. 37, 15-295 Białystok, PolandDepartment of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Żołnierska Str 18, 10-561 Olsztyn, PolandClinic of Gynecology, Oncological Gynecology and Obstetrics, Municipal Polyclinical Hospital in Olsztyn, Niepodległości Str. 44, 10-045 Olsztyn, PolandTamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium–endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (<i>p</i> < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening.https://www.mdpi.com/2077-0383/9/12/3870elastographyendometriumendometrial cancerendometrial cancer screeningSERM therapythe softest endometrium layer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Krzysztof Jabłoński Łukasz Kurek Maciej Żukowski Natalia Data-Jabłońska Karolina Żukowska Anna J. Milewska Aleksandra Lipka Marcin Jóźwik |
spellingShingle |
Krzysztof Jabłoński Łukasz Kurek Maciej Żukowski Natalia Data-Jabłońska Karolina Żukowska Anna J. Milewska Aleksandra Lipka Marcin Jóźwik Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem Journal of Clinical Medicine elastography endometrium endometrial cancer endometrial cancer screening SERM therapy the softest endometrium layer |
author_facet |
Krzysztof Jabłoński Łukasz Kurek Maciej Żukowski Natalia Data-Jabłońska Karolina Żukowska Anna J. Milewska Aleksandra Lipka Marcin Jóźwik |
author_sort |
Krzysztof Jabłoński |
title |
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem |
title_short |
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem |
title_full |
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem |
title_fullStr |
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem |
title_full_unstemmed |
Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem |
title_sort |
elastography of endometrium in women taking tamoxifen: a new approach to an old diagnostic problem |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-11-01 |
description |
Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium–endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (<i>p</i> < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening. |
topic |
elastography endometrium endometrial cancer endometrial cancer screening SERM therapy the softest endometrium layer |
url |
https://www.mdpi.com/2077-0383/9/12/3870 |
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