Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hy...

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Bibliographic Details
Main Authors: Jessica E. Frith, Gina D. Kusuma, James Carthew, Fanyi Li, Nicole Cloonan, Guillermo A. Gomez, Justin J. Cooper-White
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02486-0
Description
Summary:Mesenchymal stem cell (MSC) fate can be mechanically regulated by substrate stiffness but this is difficult to control in a 3D hydrogel. Here the authors identify miRNAs that change expression in response to substrate stiffness and RhoA signalling and show that they can bias MSC fate in a 3D soft hydrogel.
ISSN:2041-1723

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