Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide
Abstract: To investigate the mechanism of different exercise patterns on neurological function after focal cerebral ischaemia in rats. Rats with focal cerebral cerebral ischaemia were randomly divided into an aerobic exercise group, an exhaustive exercise group and a control group, with 8 rats in ea...
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doaj-88ebd5edecb249f5b8147d39d3ee46322020-11-24T21:27:49ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-269091310.1590/0001-3765201920190068S0001-37652019000500802Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxideLEI SUNLV-PING ZHUANGWEI-FENG WUAbstract: To investigate the mechanism of different exercise patterns on neurological function after focal cerebral ischaemia in rats. Rats with focal cerebral cerebral ischaemia were randomly divided into an aerobic exercise group, an exhaustive exercise group and a control group, with 8 rats in each group. A score for nerve function in each group was calculated, and the ultrastructure of nerve cells was observed. Levels of NO and NOS in the brain motor area of the rats were measured in each group. The aerobic exercise group had lower nerve function scores than the exhaustive exercise group and higher scores than the control group (P<0.05). Under transmission electron microscopy, irregular shapes and organs were observed in nerve cells in the control group, while regular cell shapes and organs were observed in the aerobic exercise group. The aerobic exercise group and exhaustive exercise group had higher measures of NO content, NOS activity and eNOS, nNOS and iNOS gene expression than the control group, but eNOS expression in the aerobic exercise group and iNOS expression in the exhaustive exercise group were clearly higher according to RT-PCR (P<0.05). Aerobic exercise can promote the expression of NOS, mainly in eNOS, which can promote nerve repair.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500802&lng=en&tlng=enexercise intensitycerebral ischaemianervous functionrepairNONOS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
LEI SUN LV-PING ZHUANG WEI-FENG WU |
spellingShingle |
LEI SUN LV-PING ZHUANG WEI-FENG WU Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide Anais da Academia Brasileira de Ciências exercise intensity cerebral ischaemia nervous function repair NO NOS |
author_facet |
LEI SUN LV-PING ZHUANG WEI-FENG WU |
author_sort |
LEI SUN |
title |
Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
title_short |
Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
title_full |
Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
title_fullStr |
Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
title_full_unstemmed |
Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
title_sort |
aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide |
publisher |
Academia Brasileira de Ciências |
series |
Anais da Academia Brasileira de Ciências |
issn |
1678-2690 |
description |
Abstract: To investigate the mechanism of different exercise patterns on neurological function after focal cerebral ischaemia in rats. Rats with focal cerebral cerebral ischaemia were randomly divided into an aerobic exercise group, an exhaustive exercise group and a control group, with 8 rats in each group. A score for nerve function in each group was calculated, and the ultrastructure of nerve cells was observed. Levels of NO and NOS in the brain motor area of the rats were measured in each group. The aerobic exercise group had lower nerve function scores than the exhaustive exercise group and higher scores than the control group (P<0.05). Under transmission electron microscopy, irregular shapes and organs were observed in nerve cells in the control group, while regular cell shapes and organs were observed in the aerobic exercise group. The aerobic exercise group and exhaustive exercise group had higher measures of NO content, NOS activity and eNOS, nNOS and iNOS gene expression than the control group, but eNOS expression in the aerobic exercise group and iNOS expression in the exhaustive exercise group were clearly higher according to RT-PCR (P<0.05). Aerobic exercise can promote the expression of NOS, mainly in eNOS, which can promote nerve repair. |
topic |
exercise intensity cerebral ischaemia nervous function repair NO NOS |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500802&lng=en&tlng=en |
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