Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides

• Main Authors: Xiaolong Fu, Peifeng Wan, Peipei Li, Jinpeng Wang, Siwei Guo, Yuan Zhang, Yachun An, Chao Ye, Ziyi Liu, Jiangang Gao, Jianming Yang, Jiangang Fan, Renjie Chai
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-06-01
• Series: Frontiers in Cellular Neuroscience
• Subjects: ototoxicity; aminoglycosides; hearing loss; mechanism; prevention
• Online Access: https://www.frontiersin.org/articles/10.3389/fncel.2021.692762/full

Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.