Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children

Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children

New diagnostic tests for the etiology of childhood pneumonia are needed. We evaluated the antibody-in-lymphocyte supernatant (ALS) assay to detect immunoglobulin (Ig) G secretion from ex vivo peripheral blood mononuclear cell (PBMC) culture, as a potential diagnostic test for pneumococcal pneumonia....

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Bibliographic Details
Main Authors: Michael J. Carter, Pallavi Gurung, Claire Jones, Shristy Rajkarnikar, Rama Kandasamy, Meeru Gurung, Stephen Thorson, Madhav C. Gautam, Krishna G. Prajapati, Bibek Khadka, Anju Maharjan, Julian C. Knight, David R. Murdoch, Thomas C. Darton, Merryn Voysey, Brian Wahl, Katherine L. O'Brien, Sarah Kelly, Imran Ansari, Ganesh Shah, Nina Ekström, Merit Melin, Andrew J. Pollard, Dominic F. Kelly, Shrijana Shrestha
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
pneumococcus (Streptococcus pneumoniae)
pneumonia
antibodies
diagnostic test (MeSH)
lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00459/full

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