Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer

Preliminary investigation of cytotoxic potential of 2-quinolone derivatives using in vitro and in vivo (solid tumor and liquid tumor) models of cancer

2-Quinolone analogs are powerful inhibitors of farnesyl transferase, and are a novel class of anticancer drugs. The present study focused on continual efforts to elucidate the anticancer activity of synthesized 2-quinolone derivatives without N-methyl or 3-aryl substitution. Three derivatives namely...

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Bibliographic Details
Main Authors: Nitesh Kumar, Isha Dhamija, P. Vasanth Raj, B.S. Jayashree, Vipan Parihar, S.N. Manjula, Seeja Thomas, N. Gopalan Kutty, C. Mallikarjuna Rao
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Arabian Journal of Chemistry
Subjects:
Cytotoxicity
Cancer
2-Quinolone
Solid tumor
Liquid tumor
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212003206

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