Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region

The theoretical titration curve of a weak acid with a strong base was considered. The limitation of the Henderson-Hasselbalch equation for the calculation of pH in the buffer region was discussed. One novel simple equation for the exact calculation of pH from the beginning of titration up to the equ...

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Main Authors:	Radić Njegomir, Prkić Ante
Format:	Article
Language:	English
Published:	De Gruyter 2012-06-01
Series:	Reviews in Analytical Chemistry
Subjects:	acid-base chemistry analytical chemistry henderson-hasselbalch equation titration
Online Access:	https://doi.org/10.1515/revac-2012-0001

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spelling	doaj-88f85a7858ae4c879580aad6ca9171722021-09-05T14:00:13ZengDe GruyterReviews in Analytical Chemistry0793-01352191-01892012-06-01312939810.1515/revac-2012-0001Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer regionRadić Njegomir0Prkić Ante1Department of Analytical Chemistry, Faculty of Chemistry and Chemical Technology, University of Split, Teslina 10/V, 21000 Split, CroatiaDepartment of Analytical Chemistry, Faculty of Chemistry and Chemical Technology, University of Split, Teslina 10/V, 21000 Split, CroatiaThe theoretical titration curve of a weak acid with a strong base was considered. The limitation of the Henderson-Hasselbalch equation for the calculation of pH in the buffer region was discussed. One novel simple equation for the exact calculation of pH from the beginning of titration up to the equivalence point was derived. By using this equation with one implicit approximation (the dissociation of water), the calculation of pH values after each addition of titrant is possible. A novel equation provides the simple and exact calculation of pH in the range of buffer, and that can be done in a simple and logical way without complex handling of acid-base equilibrium with computer and spreadsheet software. The calculated titration curves for different concentrations of acetic acid and sodium hydroxide were shown.https://doi.org/10.1515/revac-2012-0001acid-base chemistryanalytical chemistryhenderson-hasselbalch equationtitration
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Radić Njegomir Prkić Ante
spellingShingle	Radić Njegomir Prkić Ante Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region Reviews in Analytical Chemistry acid-base chemistry analytical chemistry henderson-hasselbalch equation titration
author_facet	Radić Njegomir Prkić Ante
author_sort	Radić Njegomir
title	Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region
title_short	Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region
title_full	Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region
title_fullStr	Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region
title_full_unstemmed	Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region
title_sort	historical remarks on the henderson-hasselbalch equation: its advantages and limitations and a novel approach for exact ph calculation in buffer region
publisher	De Gruyter
series	Reviews in Analytical Chemistry
issn	0793-0135 2191-0189
publishDate	2012-06-01
description	The theoretical titration curve of a weak acid with a strong base was considered. The limitation of the Henderson-Hasselbalch equation for the calculation of pH in the buffer region was discussed. One novel simple equation for the exact calculation of pH from the beginning of titration up to the equivalence point was derived. By using this equation with one implicit approximation (the dissociation of water), the calculation of pH values after each addition of titrant is possible. A novel equation provides the simple and exact calculation of pH in the range of buffer, and that can be done in a simple and logical way without complex handling of acid-base equilibrium with computer and spreadsheet software. The calculated titration curves for different concentrations of acetic acid and sodium hydroxide were shown.
topic	acid-base chemistry analytical chemistry henderson-hasselbalch equation titration
url	https://doi.org/10.1515/revac-2012-0001
work_keys_str_mv	AT radicnjegomir historicalremarksonthehendersonhasselbalchequationitsadvantagesandlimitationsandanovelapproachforexactphcalculationinbufferregion AT prkicante historicalremarksonthehendersonhasselbalchequationitsadvantagesandlimitationsandanovelapproachforexactphcalculationinbufferregion
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Historical remarks on the Henderson-Hasselbalch equation: its advantages and limitations and a novel approach for exact pH calculation in buffer region

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