Sleep-wake cycle in young and older persons with a lifetime history of mood disorders.
Considering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depres...
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doaj-88fd8e6242484b2ab8d65f3f8fb4afbc2020-11-25T00:23:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8776310.1371/journal.pone.0087763Sleep-wake cycle in young and older persons with a lifetime history of mood disorders.Rébecca RobillardSharon L NaismithKristie Leigh SmithNaomi L RogersDjango WhiteZoe TerpeningTony K C IpDaniel F HermensBradley WhitwellElizabeth M ScottIan B HickieConsidering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depression Rating Scale (HDRS) was administered to assess current symptoms severity in 238 persons with a history of a mood disorder between 12 and 90 years of age (y.o.). Actigraphy was recorded over five to 22 days. Regression analyses and analyses of variance [age (12-19 y.o., 20-39 y.o., 40-59 y.o., and ≥ 60 y.o.) by depression severity (HDRS< and ≥ 8)] were conducted. The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups. The ≥ 60 y.o. group had a lower rhythmicity and amplitude (p ≤ .006) than the 12-19 y.o. group (p ≤ .046). Participants with a HDRS ≥ 8 spent longer time in bed, had later sleep offset times and had lower circadian rhythmicity than those with a HDRS<8 (p ≤ .036). Younger age and higher HDRS score correlated with later sleep onset and offset times, longer time in bed, higher WASO, lower sleep efficiency and later acrophase (p ≤ .023). Age was a significant predictor of delayed sleep and activity schedules (p ≤ .001). The profile of sleep-wake cycle disturbances associated with mood disorders changes with age, with prominent sleep phase delay during youth and reduced circadian strength in older persons. Conversely, disruptions in sleep consolidation seem more stable across age.http://europepmc.org/articles/PMC3934865?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rébecca Robillard Sharon L Naismith Kristie Leigh Smith Naomi L Rogers Django White Zoe Terpening Tony K C Ip Daniel F Hermens Bradley Whitwell Elizabeth M Scott Ian B Hickie |
spellingShingle |
Rébecca Robillard Sharon L Naismith Kristie Leigh Smith Naomi L Rogers Django White Zoe Terpening Tony K C Ip Daniel F Hermens Bradley Whitwell Elizabeth M Scott Ian B Hickie Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. PLoS ONE |
author_facet |
Rébecca Robillard Sharon L Naismith Kristie Leigh Smith Naomi L Rogers Django White Zoe Terpening Tony K C Ip Daniel F Hermens Bradley Whitwell Elizabeth M Scott Ian B Hickie |
author_sort |
Rébecca Robillard |
title |
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
title_short |
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
title_full |
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
title_fullStr |
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
title_full_unstemmed |
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
title_sort |
sleep-wake cycle in young and older persons with a lifetime history of mood disorders. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Considering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depression Rating Scale (HDRS) was administered to assess current symptoms severity in 238 persons with a history of a mood disorder between 12 and 90 years of age (y.o.). Actigraphy was recorded over five to 22 days. Regression analyses and analyses of variance [age (12-19 y.o., 20-39 y.o., 40-59 y.o., and ≥ 60 y.o.) by depression severity (HDRS< and ≥ 8)] were conducted. The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups. The ≥ 60 y.o. group had a lower rhythmicity and amplitude (p ≤ .006) than the 12-19 y.o. group (p ≤ .046). Participants with a HDRS ≥ 8 spent longer time in bed, had later sleep offset times and had lower circadian rhythmicity than those with a HDRS<8 (p ≤ .036). Younger age and higher HDRS score correlated with later sleep onset and offset times, longer time in bed, higher WASO, lower sleep efficiency and later acrophase (p ≤ .023). Age was a significant predictor of delayed sleep and activity schedules (p ≤ .001). The profile of sleep-wake cycle disturbances associated with mood disorders changes with age, with prominent sleep phase delay during youth and reduced circadian strength in older persons. Conversely, disruptions in sleep consolidation seem more stable across age. |
url |
http://europepmc.org/articles/PMC3934865?pdf=render |
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