Non-Specific Orbital Inflammation and Sclerosing Variant

• Main Authors: Moises Enghelberg, Jonathan Go, Adam Adika, Marcos A Sanchez-Gonzalez, Dan Georgescu, Matthew Kay
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-01-01
• Series: The Pan-American Journal of Ophthalmology
• Subjects: non-specific orbital inflammation; idiopathic orbital inflammation; orbital pseudotumor; idiopathic sclerosing orbital inflammation; sclerosing variant of non-specific orbital inflammation.
• Online Access: http://www.thepajo.org/article.asp?issn=2666-4909;year=2017;volume=16;issue=4;spage=103;epage=109;aulast=Enghelberg;type=0
• ISSN: 2666-4909; 2666-4909

This systematic review of biopsy proven cases of non specific orbital inflammation and sclerosing variant from 2010-2016 attempts to elucidate new findings regarding the demographic profile of the diseases. Discussion of histopathology is emphasized, as to describe the most common presenting features of non-specific orbital inflammation as well as to discuss its molecular profile. This review also discusses the therapeutic approach and discusses the “steroids vs. biopsy first” controversy regarding non-specific orbital inflammation. The incidence of IgG4 and its relationship to non-specific orbital inflammation is also discussed.