Meta analysis of Clinical Efficacy of Traditional Chinese Medicine in the Treatment of Aplastic Anemia

• Main Authors: Le-min XIA, Le-le CUI, Yi-ling JIANG, Zheng QIN, Mei-hong LUO
• Format: Article
• Language: English
• Published: Third Party Medicine International Publishing Group Co. Limited 2018-04-01
• Series: Journal of International Translational Medicine
• Subjects: Traditional Chinese medicine; aplastic anemia; Meta analysis
• Online Access: http://dx.doi.org/10.11910/2227-6394.2018.06.01.02

Objective: To evaluate the clinical efficacy of traditional Chinese medicine (TCM) in treatment of aplastic anemia (AA), providing evidence for the development of TCM diagnosis and treatment guidelines of AA therapy. Methods: Randomized or semi-randomized control trials of AA treatments with TCM were retrieved, and the selected literatures were scored with Jadad scale. The data were extracted, and RevMan 5.2.6 software was used for meta analysis. Results: Two studies on AA treatment with Liuwei Dihuang pills combined with compound Zaofan pill were included. The results of meta analysis showed that there were no statistical significant differences in total efficiency between Liuwei Dihuang pills combined with compound Zaofan pill and androgen in the treatment of AA (P = 0.65). However, adverse reactions including liver damage and masculinization of women in the former treatment of AA, were lighter than the latter (P < 0.05). other researches on the treatment of AA with TCM were lack of clinical trials reports. Conclusions: TCM had certain curative effect in the treatment of AA. However, the quality of literature was generally low and the sample size was small, which made the validation of the results poor. Therefore, more researches with high quality were still needed to provide high level evidence.