PEPD is a pivotal regulator of p53 tumor suppressor
p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.
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2017-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02097-9 |
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doaj-8906903619f242569689966908f927ec2021-05-11T07:33:30ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-02097-9PEPD is a pivotal regulator of p53 tumor suppressorLu Yang0Yun Li1Arup Bhattacharya2Yuesheng Zhang3Department of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institutep53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.https://doi.org/10.1038/s41467-017-02097-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang |
spellingShingle |
Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang PEPD is a pivotal regulator of p53 tumor suppressor Nature Communications |
author_facet |
Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang |
author_sort |
Lu Yang |
title |
PEPD is a pivotal regulator of p53 tumor suppressor |
title_short |
PEPD is a pivotal regulator of p53 tumor suppressor |
title_full |
PEPD is a pivotal regulator of p53 tumor suppressor |
title_fullStr |
PEPD is a pivotal regulator of p53 tumor suppressor |
title_full_unstemmed |
PEPD is a pivotal regulator of p53 tumor suppressor |
title_sort |
pepd is a pivotal regulator of p53 tumor suppressor |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-12-01 |
description |
p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals. |
url |
https://doi.org/10.1038/s41467-017-02097-9 |
work_keys_str_mv |
AT luyang pepdisapivotalregulatorofp53tumorsuppressor AT yunli pepdisapivotalregulatorofp53tumorsuppressor AT arupbhattacharya pepdisapivotalregulatorofp53tumorsuppressor AT yueshengzhang pepdisapivotalregulatorofp53tumorsuppressor |
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1721452026297057280 |