PEPD is a pivotal regulator of p53 tumor suppressor

PEPD is a pivotal regulator of p53 tumor suppressor

p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.

Bibliographic Details
Main Authors: Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02097-9
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spelling doaj-8906903619f242569689966908f927ec2021-05-11T07:33:30ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-02097-9PEPD is a pivotal regulator of p53 tumor suppressorLu Yang0Yun Li1Arup Bhattacharya2Yuesheng Zhang3Department of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer InstituteDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institutep53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.https://doi.org/10.1038/s41467-017-02097-9
collection DOAJ
language English
format Article
sources DOAJ
author Lu Yang
Yun Li
Arup Bhattacharya
Yuesheng Zhang
spellingShingle Lu Yang
Yun Li
Arup Bhattacharya
Yuesheng Zhang
PEPD is a pivotal regulator of p53 tumor suppressor
Nature Communications
author_facet Lu Yang
Yun Li
Arup Bhattacharya
Yuesheng Zhang
author_sort Lu Yang
title PEPD is a pivotal regulator of p53 tumor suppressor
title_short PEPD is a pivotal regulator of p53 tumor suppressor
title_full PEPD is a pivotal regulator of p53 tumor suppressor
title_fullStr PEPD is a pivotal regulator of p53 tumor suppressor
title_full_unstemmed PEPD is a pivotal regulator of p53 tumor suppressor
title_sort pepd is a pivotal regulator of p53 tumor suppressor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.
url https://doi.org/10.1038/s41467-017-02097-9
work_keys_str_mv AT luyang pepdisapivotalregulatorofp53tumorsuppressor
AT yunli pepdisapivotalregulatorofp53tumorsuppressor
AT arupbhattacharya pepdisapivotalregulatorofp53tumorsuppressor
AT yueshengzhang pepdisapivotalregulatorofp53tumorsuppressor
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