PEPD is a pivotal regulator of p53 tumor suppressor
p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.
Main Authors: | Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02097-9 |
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