Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect the epigenetic regulatory machinery and signaling molecules, leading to a block in hematopoietic differentiation. Constitutive signaling from mutated growth factor receptors is a major driver of leukemic growth, but how...
Main Authors: | Pierre Cauchy, Sally R. James, Joaquin Zacarias-Cabeza, Anetta Ptasinska, Maria Rosaria Imperato, Salam A. Assi, Jason Piper, Martina Canestraro, Maarten Hoogenkamp, Manoj Raghavan, Justin Loke, Susanna Akiki, Samuel J. Clokie, Stephen J. Richards, David R. Westhead, Michael J. Griffiths, Sascha Ott, Constanze Bonifer, Peter N. Cockerill |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-08-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471500707X |
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