MicroRNA Machinery Genes as Novel Biomarkers for Cancer
MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemica...
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Frontiers Media S.A.
2014-05-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00113/full |
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doaj-8910fc7c2d654ac98ae0d2bc1e8881082020-11-24T22:58:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-05-01410.3389/fonc.2014.0011389675MicroRNA Machinery Genes as Novel Biomarkers for CancerJing-Tao eHuang0Jin eWang1Vibhuti eSrivastava2Subrata eSen3Song-Mei eLiu4The University of Texas M.D. Anderson Cancer CenterThe University of Texas M.D. Anderson Cancer CenterThe University of Texas M.D. Anderson Cancer CenterThe University of Texas M.D. Anderson Cancer CenterThe University of Texas M.D. Anderson Cancer CenterMicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye towards understanding how they could serve as cancer biomarkers.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00113/fullCancermiRNAbiomarkermachinery genesalterations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing-Tao eHuang Jin eWang Vibhuti eSrivastava Subrata eSen Song-Mei eLiu |
spellingShingle |
Jing-Tao eHuang Jin eWang Vibhuti eSrivastava Subrata eSen Song-Mei eLiu MicroRNA Machinery Genes as Novel Biomarkers for Cancer Frontiers in Oncology Cancer miRNA biomarker machinery genes alterations |
author_facet |
Jing-Tao eHuang Jin eWang Vibhuti eSrivastava Subrata eSen Song-Mei eLiu |
author_sort |
Jing-Tao eHuang |
title |
MicroRNA Machinery Genes as Novel Biomarkers for Cancer |
title_short |
MicroRNA Machinery Genes as Novel Biomarkers for Cancer |
title_full |
MicroRNA Machinery Genes as Novel Biomarkers for Cancer |
title_fullStr |
MicroRNA Machinery Genes as Novel Biomarkers for Cancer |
title_full_unstemmed |
MicroRNA Machinery Genes as Novel Biomarkers for Cancer |
title_sort |
microrna machinery genes as novel biomarkers for cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2014-05-01 |
description |
MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye towards understanding how they could serve as cancer biomarkers. |
topic |
Cancer miRNA biomarker machinery genes alterations |
url |
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00113/full |
work_keys_str_mv |
AT jingtaoehuang micrornamachinerygenesasnovelbiomarkersforcancer AT jinewang micrornamachinerygenesasnovelbiomarkersforcancer AT vibhutiesrivastava micrornamachinerygenesasnovelbiomarkersforcancer AT subrataesen micrornamachinerygenesasnovelbiomarkersforcancer AT songmeieliu micrornamachinerygenesasnovelbiomarkersforcancer |
_version_ |
1725646696690483200 |