Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant
Background: Deep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease. Methods: We describe three patients with previous effectiv...
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doaj-89262d581ba7433d8e3893c4c32750192021-03-18T04:37:19ZengElsevierBrain Stimulation1935-861X2014-03-0172179181Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus ImplantBrigida Minafra0Alfonso Fasano1Nicolò Gabriele Pozzi2Roberta Zangaglia3Domenico Servello4Claudio Pacchetti5Parkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy; Interdepartmental Research Center for Neurodegenerative Disease, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy; Corresponding author. Parkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy. Tel.: +39 0382 380221; fax: +39 0382 380226.Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, CanadaParkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy; Interdepartmental Research Center for Neurodegenerative Disease, National Institute of Neurology Foundation “C. Mondino”, Pavia, ItalyParkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy; Interdepartmental Research Center for Neurodegenerative Disease, National Institute of Neurology Foundation “C. Mondino”, Pavia, ItalyFunctional Neurosurgical Unit, IRCCS “Galeazzi”, Milano, ItalyParkinson's Disease and Movement Disorders Unit, National Institute of Neurology Foundation “C. Mondino”, Pavia, Italy; Interdepartmental Research Center for Neurodegenerative Disease, National Institute of Neurology Foundation “C. Mondino”, Pavia, ItalyBackground: Deep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease. Methods: We describe three patients with previous effective subthalamic deep brain stimulation in whom globus pallidus interna deep brain stimulation was performed as “rescue” surgery, 8 years after the original operation. Results: Two years after globus pallidus surgery the reduction of dystonia and dyskinesias led to an improvement of motor symptoms. In two patients, painful dystonias disappeared and motor fluctuations markedly improved. One patient achieved an improvement in freezing. Conclusion: After 24 months of follow up, our observations suggest that globus pallidus deep brain stimulation, can improve motor fluctuations, dyskinesia and axial symptoms.http://www.sciencedirect.com/science/article/pii/S1935861X1300404XParkinson's diseaseDeep brain stimulationSubthalamic nucleusGlobus pallidus interna |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brigida Minafra Alfonso Fasano Nicolò Gabriele Pozzi Roberta Zangaglia Domenico Servello Claudio Pacchetti |
spellingShingle |
Brigida Minafra Alfonso Fasano Nicolò Gabriele Pozzi Roberta Zangaglia Domenico Servello Claudio Pacchetti Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant Brain Stimulation Parkinson's disease Deep brain stimulation Subthalamic nucleus Globus pallidus interna |
author_facet |
Brigida Minafra Alfonso Fasano Nicolò Gabriele Pozzi Roberta Zangaglia Domenico Servello Claudio Pacchetti |
author_sort |
Brigida Minafra |
title |
Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant |
title_short |
Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant |
title_full |
Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant |
title_fullStr |
Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant |
title_full_unstemmed |
Eight-years Failure of Subthalamic Stimulation Rescued by Globus Pallidus Implant |
title_sort |
eight-years failure of subthalamic stimulation rescued by globus pallidus implant |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-03-01 |
description |
Background: Deep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease. Methods: We describe three patients with previous effective subthalamic deep brain stimulation in whom globus pallidus interna deep brain stimulation was performed as “rescue” surgery, 8 years after the original operation. Results: Two years after globus pallidus surgery the reduction of dystonia and dyskinesias led to an improvement of motor symptoms. In two patients, painful dystonias disappeared and motor fluctuations markedly improved. One patient achieved an improvement in freezing. Conclusion: After 24 months of follow up, our observations suggest that globus pallidus deep brain stimulation, can improve motor fluctuations, dyskinesia and axial symptoms. |
topic |
Parkinson's disease Deep brain stimulation Subthalamic nucleus Globus pallidus interna |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X1300404X |
work_keys_str_mv |
AT brigidaminafra eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant AT alfonsofasano eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant AT nicologabrielepozzi eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant AT robertazangaglia eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant AT domenicoservello eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant AT claudiopacchetti eightyearsfailureofsubthalamicstimulationrescuedbyglobuspallidusimplant |
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