A systematic review of gold nanoparticles as novel cancer therapeutics
Objective(s): The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy. Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of know...
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Mashhad University of Medical Sciences
2014-09-01
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doaj-893157ef4a21406eae20c1438b0bf0472020-11-24T20:54:12ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042014-09-01142112192711A systematic review of gold nanoparticles as novel cancer therapeuticsMohammad Babaei0Maryam Ganjalikhani1Department of Radiotherapy Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranResearcher and general practitioner, Tehran University of Medical Sciences, Tehran, Iran Objective(s): The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy. Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies. Any study that assessed nanoparticles, candidate of radio enhancement at radiotherapy on animals or cell lines was included by two independent reviewers. Results: Gold nanoparticles can enhance radiosenstivity of tumor cells. This effect is shown in vivo and in vitro, at kilovoltage or megavoltage energies, in 15 reviewed studies. Emphasis of studies was on gold nanoparticles. Radiosensitization of nanoparticles depend on nanoparticles’ size, type, concentration, intracellular localization, used irradiation energy and tested cell line. Conclusion: Study outcomes have showed that gold nanoparticles have been beneficial at cancer radiation therapy. http://nmj.mums.ac.ir/pdf_2711_52b8be5bb3167342af49834f752b0008.htmlKeywords: Gold nanoparticlesRadio sensitizerRadiation therapysystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Babaei Maryam Ganjalikhani |
spellingShingle |
Mohammad Babaei Maryam Ganjalikhani A systematic review of gold nanoparticles as novel cancer therapeutics Nanomedicine Journal Keywords: Gold nanoparticles Radio sensitizer Radiation therapy systematic review |
author_facet |
Mohammad Babaei Maryam Ganjalikhani |
author_sort |
Mohammad Babaei |
title |
A systematic review of gold nanoparticles as novel cancer therapeutics |
title_short |
A systematic review of gold nanoparticles as novel cancer therapeutics |
title_full |
A systematic review of gold nanoparticles as novel cancer therapeutics |
title_fullStr |
A systematic review of gold nanoparticles as novel cancer therapeutics |
title_full_unstemmed |
A systematic review of gold nanoparticles as novel cancer therapeutics |
title_sort |
systematic review of gold nanoparticles as novel cancer therapeutics |
publisher |
Mashhad University of Medical Sciences |
series |
Nanomedicine Journal |
issn |
2322-3049 2322-5904 |
publishDate |
2014-09-01 |
description |
Objective(s): The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy. Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies. Any study that assessed nanoparticles, candidate of radio enhancement at radiotherapy on animals or cell lines was included by two independent reviewers. Results: Gold nanoparticles can enhance radiosenstivity of tumor cells. This effect is shown in vivo and in vitro, at kilovoltage or megavoltage energies, in 15 reviewed studies. Emphasis of studies was on gold nanoparticles. Radiosensitization of nanoparticles depend on nanoparticles’ size, type, concentration, intracellular localization, used irradiation energy and tested cell line. Conclusion: Study outcomes have showed that gold nanoparticles have been beneficial at cancer radiation therapy. |
topic |
Keywords: Gold nanoparticles Radio sensitizer Radiation therapy systematic review |
url |
http://nmj.mums.ac.ir/pdf_2711_52b8be5bb3167342af49834f752b0008.html |
work_keys_str_mv |
AT mohammadbabaei asystematicreviewofgoldnanoparticlesasnovelcancertherapeutics AT maryamganjalikhani asystematicreviewofgoldnanoparticlesasnovelcancertherapeutics AT mohammadbabaei systematicreviewofgoldnanoparticlesasnovelcancertherapeutics AT maryamganjalikhani systematicreviewofgoldnanoparticlesasnovelcancertherapeutics |
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1716795220985643008 |