The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer
A hallmark of Spemann organizer function is its expression of Wnt antagonists that regulate axial embryonic patterning. Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-type kappa (PTPRK), as a Wnt inhibitor in human cancer cells and in the Spemann organizer of Xenopus emb...
Main Authors: | Ling-Shih Chang, Minseong Kim, Andrey Glinka, Carmen Reinhard, Christof Niehrs |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/51248 |
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