Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction
Objective: Characteristic parkinsonism is the major comorbidity of dementia with Lewy bodies (DLB). We aimed to differentiate DLB from Alzheimer's disease (AD) with motor dysfunction using a composite scale with a characteristic motor dysfunction questionnaire (MDQ) and dopamine transporter (DA...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
|
Series: | Frontiers in Aging Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.709215/full |
id |
doaj-8932fcbf7f484ba598a0f01f1506867d |
---|---|
record_format |
Article |
spelling |
doaj-8932fcbf7f484ba598a0f01f1506867d2021-08-11T07:34:04ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.709215709215Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor DysfunctionPai-Yi Chiu0Pai-Yi Chiu1Cheng-Yu Wei2Guang-Uei Hung3Shey-Lin Wu4Shey-Lin Wu5Department of Neurology, Show Chwan Memorial Hospital, Changhua, TaiwanDepartment of Nursing, College of Nursing and Health Sciences, Da-Yeh University, Changhua, TaiwanDepartment of Neurology, Chang Bing Show Chwan Memorial Hospital, Changhua, TaiwanDepartment of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua, TaiwanDepartment of Neurology, Changhua Christian Hospital, Changhua, TaiwanDepartment of Biomedical Sciences, Da-Yeh University,Changhua, TaiwanObjective: Characteristic parkinsonism is the major comorbidity of dementia with Lewy bodies (DLB). We aimed to differentiate DLB from Alzheimer's disease (AD) with motor dysfunction using a composite scale with a characteristic motor dysfunction questionnaire (MDQ) and dopamine transporter (DAT) imaging. It could help detect DLB easily in healthcare settings without movement disorder specialists.Methods: This is a two-phase study. In the design phase, seven questions were selected and composed of a novel MDQ. In the test phase, all participants with DLB, AD, or non-dementia (ND) control completed dementia and parkinsonism survey, the novel designed questionnaire, DAT imaging, and composite scales of MDQ and DAT. The cutoff scores of the MDQ, semiquantitative analysis of the striatal–background ratio (SBR) and visual rating of DAT, and the composite scale of MDQ and DAT for discriminating DLB from AD or ND were derived and compared.Results: A total of 277 participants were included in this study (126 with DLB, 86 with AD, and 65 with ND). Compared with the AD or ND groups, the DLB group showed a significantly higher frequency in all seven items in the MDQ and a significantly lower SBR. For discrimination of DLB from non-DLB with MDQ, SBR, and composite scale, the cutoff scores of 3/2, 1.37/1.38, and 6/5 were suggested for the diagnosis of DLB with the sensitivities/specificities of 0.91/0.72, 0.91/0.80, and 0.87/0.93, respectively. The composite scale significantly improved the accuracy of discrimination compared with either the MDQ or SBR.Conclusion: This study showed that the novel designed simple questionnaire was a practical screening tool and had similar power to DAT scanning to detect DLB. The questionnaire can be applied in clinical practice and population studies for screening DLB. In addition, the composite scale of MDQ and DAT imaging further improved the diagnostic accuracy, indicating the superiority of the dual-model diagnostic tool.https://www.frontiersin.org/articles/10.3389/fnagi.2021.709215/fullAlzheimer's diseasedementia with Lewy bodiesnon-dementiamotor dysfunctionstriatal–background ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pai-Yi Chiu Pai-Yi Chiu Cheng-Yu Wei Guang-Uei Hung Shey-Lin Wu Shey-Lin Wu |
spellingShingle |
Pai-Yi Chiu Pai-Yi Chiu Cheng-Yu Wei Guang-Uei Hung Shey-Lin Wu Shey-Lin Wu Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction Frontiers in Aging Neuroscience Alzheimer's disease dementia with Lewy bodies non-dementia motor dysfunction striatal–background ratio |
author_facet |
Pai-Yi Chiu Pai-Yi Chiu Cheng-Yu Wei Guang-Uei Hung Shey-Lin Wu Shey-Lin Wu |
author_sort |
Pai-Yi Chiu |
title |
Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction |
title_short |
Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction |
title_full |
Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction |
title_fullStr |
Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction |
title_full_unstemmed |
Motor Dysfunction Questionnaire and Dopamine Transporter Imaging Composite Scale Improve Differentiating Dementia With Lewy Bodies From Alzheimer's Disease With Motor Dysfunction |
title_sort |
motor dysfunction questionnaire and dopamine transporter imaging composite scale improve differentiating dementia with lewy bodies from alzheimer's disease with motor dysfunction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-08-01 |
description |
Objective: Characteristic parkinsonism is the major comorbidity of dementia with Lewy bodies (DLB). We aimed to differentiate DLB from Alzheimer's disease (AD) with motor dysfunction using a composite scale with a characteristic motor dysfunction questionnaire (MDQ) and dopamine transporter (DAT) imaging. It could help detect DLB easily in healthcare settings without movement disorder specialists.Methods: This is a two-phase study. In the design phase, seven questions were selected and composed of a novel MDQ. In the test phase, all participants with DLB, AD, or non-dementia (ND) control completed dementia and parkinsonism survey, the novel designed questionnaire, DAT imaging, and composite scales of MDQ and DAT. The cutoff scores of the MDQ, semiquantitative analysis of the striatal–background ratio (SBR) and visual rating of DAT, and the composite scale of MDQ and DAT for discriminating DLB from AD or ND were derived and compared.Results: A total of 277 participants were included in this study (126 with DLB, 86 with AD, and 65 with ND). Compared with the AD or ND groups, the DLB group showed a significantly higher frequency in all seven items in the MDQ and a significantly lower SBR. For discrimination of DLB from non-DLB with MDQ, SBR, and composite scale, the cutoff scores of 3/2, 1.37/1.38, and 6/5 were suggested for the diagnosis of DLB with the sensitivities/specificities of 0.91/0.72, 0.91/0.80, and 0.87/0.93, respectively. The composite scale significantly improved the accuracy of discrimination compared with either the MDQ or SBR.Conclusion: This study showed that the novel designed simple questionnaire was a practical screening tool and had similar power to DAT scanning to detect DLB. The questionnaire can be applied in clinical practice and population studies for screening DLB. In addition, the composite scale of MDQ and DAT imaging further improved the diagnostic accuracy, indicating the superiority of the dual-model diagnostic tool. |
topic |
Alzheimer's disease dementia with Lewy bodies non-dementia motor dysfunction striatal–background ratio |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.709215/full |
work_keys_str_mv |
AT paiyichiu motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction AT paiyichiu motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction AT chengyuwei motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction AT guangueihung motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction AT sheylinwu motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction AT sheylinwu motordysfunctionquestionnaireanddopaminetransporterimagingcompositescaleimprovedifferentiatingdementiawithlewybodiesfromalzheimersdiseasewithmotordysfunction |
_version_ |
1721211570218860544 |