Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia
Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patien...
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Tehran University of Medical Sciences
2012-07-01
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doaj-893613d3dde047008d33c4f306a4de782020-11-25T01:46:22ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-07-01507Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid LeukemiaAli Esfahani0Zohreh Ghoreishi1Alireza Nikanfar2Zohreh Sanaat3Amir Ghorbanihaghjo4Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Nutrition and Biochemistry, School of Health Sciences, Tehran University of Medical Sciences, Tehran, Iran.Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. All patients received cytarabine and daunorubicin as chemotherapy regimen. Plasma levels of malondialdehyde (MDA), total antioxidant status (TAS), and the levels of erythrocyte activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined before chemotherapy and 14 days after chemotherapy with cytarabine and daunorubicin. Plasma MDA concentrations increased significantly (from 2.68±0.89 nmol/L to 3.14±1.29 nmol/L) during the 14days post-chemotherapy period (P=0.04). Plasma TAS concentrations changed with chemotherapy from 1.09±0.15 mmol/L to 1.02±0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24±543.61 U/g Hb to 984.01±419.09 U/g Hb (P=0.04) and 46.96±13.70 U/g Hb to 41.40±6.44 U/g Hb (P=0.02) respectively. We report here that there is an increase in malondialdehyde levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs. https://acta.tums.ac.ir/index.php/acta/article/view/3929Acute myeloid leukemiaChemotherapyOxidative stressAntioxidant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Esfahani Zohreh Ghoreishi Alireza Nikanfar Zohreh Sanaat Amir Ghorbanihaghjo |
spellingShingle |
Ali Esfahani Zohreh Ghoreishi Alireza Nikanfar Zohreh Sanaat Amir Ghorbanihaghjo Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia Acta Medica Iranica Acute myeloid leukemia Chemotherapy Oxidative stress Antioxidant |
author_facet |
Ali Esfahani Zohreh Ghoreishi Alireza Nikanfar Zohreh Sanaat Amir Ghorbanihaghjo |
author_sort |
Ali Esfahani |
title |
Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia |
title_short |
Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia |
title_full |
Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia |
title_fullStr |
Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia |
title_full_unstemmed |
Influence of Chemotherapy on the Lipid Peroxidation and Antioxidant Status in Patients with Acute Myeloid Leukemia |
title_sort |
influence of chemotherapy on the lipid peroxidation and antioxidant status in patients with acute myeloid leukemia |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2012-07-01 |
description |
Chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. In this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (AML). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. All patients received cytarabine and daunorubicin as chemotherapy regimen. Plasma levels of malondialdehyde (MDA), total antioxidant status (TAS), and the levels of erythrocyte activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined before chemotherapy and 14 days after chemotherapy with cytarabine and daunorubicin. Plasma MDA concentrations increased significantly (from 2.68±0.89 nmol/L to 3.14±1.29 nmol/L) during the 14days post-chemotherapy period (P=0.04). Plasma TAS concentrations changed with chemotherapy from 1.09±0.15 mmol/L to 1.02±0.14 mmol/L with P=0.005. Erythrocyte SOD and GPX activity decreased overtime from 1157.24±543.61 U/g Hb to 984.01±419.09 U/g Hb (P=0.04) and 46.96±13.70 U/g Hb to 41.40±6.44 U/g Hb (P=0.02) respectively. We report here that there is an increase in malondialdehyde levels and a decrease in the levels of antioxidant enzymes and total antioxidant status. This suggests that chemotherapy causes these changes as a result of enormous production of reactive oxygen species in the patients with AML. Antioxidant supplementation must be approached with caution because of the probability of reduction the therapeutic efficacy of these cytotoxic drugs.
|
topic |
Acute myeloid leukemia Chemotherapy Oxidative stress Antioxidant |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/3929 |
work_keys_str_mv |
AT aliesfahani influenceofchemotherapyonthelipidperoxidationandantioxidantstatusinpatientswithacutemyeloidleukemia AT zohrehghoreishi influenceofchemotherapyonthelipidperoxidationandantioxidantstatusinpatientswithacutemyeloidleukemia AT alirezanikanfar influenceofchemotherapyonthelipidperoxidationandantioxidantstatusinpatientswithacutemyeloidleukemia AT zohrehsanaat influenceofchemotherapyonthelipidperoxidationandantioxidantstatusinpatientswithacutemyeloidleukemia AT amirghorbanihaghjo influenceofchemotherapyonthelipidperoxidationandantioxidantstatusinpatientswithacutemyeloidleukemia |
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