Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis

Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis

Abstract Global DNA hypomethylation is a most common epigenetic alteration in human neoplasia. However, accumulative evidence shows that global DNA hypomethylation impacts tumorigenesis in a tissue-specific manner, promoting tumorigenesis in some but suppressing tumorigenesis in others including col...

Full description

Bibliographic Details
Main Authors:	Xiaoya Duan, Yuanyong Huang, Xiaoxing Chen, Wencai Wang, Jiwei Chen, Jialun Li, Wei Yang, Jiwen Li, Qihan Wu, Jiemin Wong
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Oncogenesis
Online Access:	https://doi.org/10.1038/s41389-021-00328-9

Similar Items

Caspases: An apoptosis mediator
by: Tapan Kumar Palai, et al.
Published: (2015-03-01)

Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
by: Bénédicte Foveau, et al.
Published: (2014-01-01)

Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis
by: Wenjin Liang, et al.
Published: (2017-05-01)

Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma.
by: Pei-Feng Liu, et al.
Published: (2017-01-01)

Purpurin triggers caspase-independent apoptosis in Candida dubliniensis biofilms.
by: Paul Wai-Kei Tsang, et al.
Published: (2013-01-01)

Induction of apoptosis and tumorigenesis inhibition by PT-262
by: Li, Jin- Yi, et al.
Published: (2010)

Mouse modifiers of intestinal tumorigenesis
by: Hong, Karen H. (Karen Hsiao-Ying), 1971-
Published: (2005)

Hypomethylating Agents in Oncohematology
by: AD Shirin,, et al.
Published: (2016-10-01)

Hypomethylated genes in neuroblastoma
by: Almutair, Bader Obaid Shreid
Published: (2017)

Brainiac Caspases: Beyond the Wall of Apoptosis
by: Ana María Espinosa-Oliva, et al.
Published: (2019-11-01)

Analysis of the role of caspase 2 in apoptosis
by: Dost, Britta
Published: (1998)

Intestinal Iron Homeostasis and Colon Tumorigenesis
by: Yatrik M. Shah, et al.
Published: (2013-06-01)

Cyclooxygenase 2 expression in intestinal tumorigenesis
by: Faluyi, Olusola Olusesan
Published: (2003)

MicroRNA-224 Promotes Tumorigenesis through Downregulation of Caspase-9 in Triple-Negative Breast Cancer
by: Li Zhang, et al.
Published: (2019-01-01)

The Link Between Hyperhomocysteinemia and Hypomethylation
by: Madalena Barroso PhD, et al.
Published: (2017-04-01)

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis
by: Baktiar Omer Karim, et al.
Published: (2014-11-01)

MicroRNA-122 regulates caspase-8 and promotes the apoptosis of mouse cardiomyocytes
by: Z.W. Zhang, et al.

Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells
by: Muhammad Khan, et al.
Published: (2012-01-01)

The Caspase Cascade of JEV Induce Cell Apoptosis
by: 游漢鵬
Published: (2000)

Caspases and the molecular control of apoptosis in leukaemic cells
by: Longthorne, Vanessa L.
Published: (1997)

Apaf-1- and Caspase-8-independent apoptosis
by: Imao, Takeshi
Published: (2013)

Exosomal transfer of miR-15b-3p enhances tumorigenesis and malignant transformation through the DYNLT1/Caspase-3/Caspase-9 signaling pathway in gastric cancer
by: Shuchun Wei, et al.
Published: (2020-02-01)

Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors
by: Qing-Yu Xu, et al.
Published: (2020-03-01)

Inhibitory role of Gas6 in intestinal tumorigenesis
by: Kawano(Akitake), Reiko
Published: (2014)

Cited1 deficiency suppresses intestinal tumorigenesis.
by: Valérie Méniel, et al.
Published: (2013-01-01)

Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis
by: Rajni Kumari, et al.
Published: (2019-09-01)

A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells
by: Zhifang Xu, et al.
Published: (2009-01-01)

Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells
by: Harald F. Krug
Published: (2012-01-01)

Corrigendum to “Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells”
by: Muhammad Khan, et al.
Published: (2020-01-01)

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes.
by: Shauna M Crowley, et al.
Published: (2020-04-01)

Hypomethylating Therapies in the Treatment of AML in the Elderly
by: João Pedro Enes da Silva
Published: (2019)

DNA hypomethylation in radiosensitivity and genomic stability
by: Armstrong, Christine
Published: (2011)

DNA hypomethylation and gene expression in mice
by: Behnam, Yousif Toma
Published: (1992)

Studies on DNA methylation and mechanisms of hypomethylation
by: Hepburn, Paul A.
Published: (1990)

ABH2 Couples Regulation of Ribosomal DNA Transcription with DNA Alkylation Repair
by: Pishun Li, et al.
Published: (2013-08-01)

The prognostic value of global DNA hypomethylation in cancer: a meta-analysis.
by: Jinhui Li, et al.
Published: (2014-01-01)

The Role of SIM2 in Regulating Intestinal Innate Immunity and Colon Tumorigenesis
by: Kuan-Jung Chen, et al.
Published: (2012)

Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis
by: Hongjie Wang, et al.
Published: (2020-06-01)

Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation.
by: Nicholas C Wong, et al.
Published: (2006-02-01)

Caspases in the Developing Central Nervous System: Apoptosis and Beyond
by: Trang Thi Minh Nguyen, et al.
Published: (2021-07-01)