Pitfalls in the Serological Diagnosis of Primary Human Cytomegalovirus Infection in Pregnancy Due to Different Kinetics of IgM Clearance and IgG Avidity Index Maturation

Pitfalls in the Serological Diagnosis of Primary Human Cytomegalovirus Infection in Pregnancy Due to Different Kinetics of IgM Clearance and IgG Avidity Index Maturation

Primary infection occurs when seronegative women are infected by human cytomegalovirus (HCMV). Diagnosis of primary infection is based on the following: antibody seroconversion, presence of IgM and low IgG avidity index (AI), and presence of DNAemia. The kinetics of HCMV-specific IgM antibody and ma...

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Bibliographic Details
Main Authors: Antonella Sarasini, Alessia Arossa, Maurizio Zavattoni, Chiara Fornara, Daniele Lilleri, Arsenio Spinillo, Fausto Baldanti, Milena Furione
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Diagnostics
Subjects:
HCMV primary infection
pregnancy
IgM antibody
IgG antibody
IgG avidity
DNAemia
Online Access:https://www.mdpi.com/2075-4418/11/3/396

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