Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies
AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of PubMed and EMBASE to identify cohort studies examining...
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doaj-894a174f26dc4a78932f18f43e7e6e752020-11-25T02:22:54ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982020-04-0113465065910.18240/ijo.2020.04.19Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studiesChao-Ran Li0Lang Chen1Long-Fei Wang2Bin Yan3You-Ling Liang4Jing Luo5Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, ChinaGeneral Surgery Department, the Third Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, ChinaCardiovascular Department, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, ChinaAIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of PubMed and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis (PsA)]. We used a random-effects model to calculate the pooled relative risks (RRs) adjusted for confounders, along with the 95% confidence intervals (CIs). RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis (RR=1.49; 95%CI: 1.08-2.07), and PsA (RR=3.16; 95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis (RR=1.62; 95%CI: 1.44-1.83), and PsA (RR=4.44; 95%CI: 3.52-5.60). CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease (psoriasis and PsA), warranting increased awareness among clinicians involved in the management of these two conditions. Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis.http://www.ijo.cn/en_publish/2020/4/20200419.pdfmeta-analysispsoriasispsoriatic arthritisriskuveitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao-Ran Li Lang Chen Long-Fei Wang Bin Yan You-Ling Liang Jing Luo |
spellingShingle |
Chao-Ran Li Lang Chen Long-Fei Wang Bin Yan You-Ling Liang Jing Luo Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies International Journal of Ophthalmology meta-analysis psoriasis psoriatic arthritis risk uveitis |
author_facet |
Chao-Ran Li Lang Chen Long-Fei Wang Bin Yan You-Ling Liang Jing Luo |
author_sort |
Chao-Ran Li |
title |
Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies |
title_short |
Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies |
title_full |
Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies |
title_fullStr |
Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies |
title_full_unstemmed |
Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies |
title_sort |
association between uveitis and psoriatic disease: a systematic review and meta-analysis based on the evidence from cohort studies |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2020-04-01 |
description |
AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other.
METHODS: We performed a comprehensive search of PubMed and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis (PsA)]. We used a random-effects model to calculate the pooled relative risks (RRs) adjusted for confounders, along with the 95% confidence intervals (CIs).
RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis (RR=1.49; 95%CI: 1.08-2.07), and PsA (RR=3.16; 95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis (RR=1.62; 95%CI: 1.44-1.83), and PsA (RR=4.44; 95%CI: 3.52-5.60).
CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease (psoriasis and PsA), warranting increased awareness among clinicians involved in the management of these two conditions. Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis. |
topic |
meta-analysis psoriasis psoriatic arthritis risk uveitis |
url |
http://www.ijo.cn/en_publish/2020/4/20200419.pdf |
work_keys_str_mv |
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