Relationship between Dyslipidemia and Glycemic Status in Type-2 Diabetes Mellitus
Introduction: India has among the largest number of diabetic subjects in the world. Dyslipidemia is a lipoprotein metabolic abnormality leading to a persistent increase in the plasmatic concentration of cholesterol and triglycerides. Studies found that increased triglyceride levels and decreased...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Pvt. Ltd.
2019-10-01
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Series: | National Journal of Laboratory Medicine |
Subjects: | |
Online Access: | http://www.njlm.net/articles/PDF/2371/42887_final%20for%20CE_F(SHU)_PF1(Su_SHU)_PFA(KM)_PN(SHU).pdf |
Summary: | Introduction: India has among the largest number of diabetic
subjects in the world. Dyslipidemia is a lipoprotein metabolic
abnormality leading to a persistent increase in the plasmatic
concentration of cholesterol and triglycerides. Studies found
that increased triglyceride levels and decreased HDL cholesterol
levels predicted Coronary Heart Disease (CHD). HDL may be the
most consistent predictor of CHD in type 2 diabetes subjects,
followed by triglyceride and total cholesterol.
Aim: To assess the link between HDL/LDL ratio and diabetic
status of patients and to compare HbA1c and FBS with HDL/
LDL ratio.
Materials and Methods: This was a retrospective crosssectional study done over a period of 1 year; in the clinical
biochemistry department of a tertiary care rural centre. Before
starting the study, the protocol was prepared and presented
to Institutional Human Research Ethics Committee which was
subsequently approved. The data for 101 diabetic patients and
106 non-diabetics were considered, who attended the hospital
for their routine health check-up. The following were noted from
the online data centre and filled into a proforma-FBS, PP2BS,
HbA1c, HDL, LDL, Tc/HDL, HDL/LDL. p-value of less than 0.05
was considered statistically significant.
Results: There was significant increase in the levels of FBS and
HbA1c in diabetic group compared to the control group. The level
of HDL gradually decreased, the level of LDL increased,while
the HDL: LDL ratio significantly was less in the diabetic group.
Conclusion: It can be concluded that diabetes mellitus type 2 is
strongly associated with lower level of high density lipoprotein
and higher level of low density lipoprotein cholesterol due to
which there is alteration in the HDL/LDL ratio. |
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ISSN: | 2277-8551 2455-6882 |