Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.

Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.

Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a...

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Bibliographic Details
Main Authors: Sofia Esteves, Sara Duarte-Silva, Luana Naia, Andreia Neves-Carvalho, Andreia Teixeira-Castro, Ana Cristina Rego, Anabela Silva-Fernandes, Patrícia Maciel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4624233?pdf=render

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