Apolipoproteins and cancer

• Main Authors: Liwen Ren, Jie Yi, Wan Li, Xiangjin Zheng, Jinyi Liu, Jinhua Wang, Guanhua Du
• Format: Article
• Language: English
• Published: Wiley 2019-11-01
• Series: Cancer Medicine
• Subjects: apolipoprotein; autophagy; cancer; drug resistance; oxidative stress
• Online Access: https://doi.org/10.1002/cam4.2587

Abstract The role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress, and drug resistance. The potential application of apolipoproteins as biomarkers for cancer diagnosis and prognosis was highlighted, together with an investigation of their potential as drug targets for cancer treatment. Many important roles of apolipoproteins and their mechanisms in cancers were reviewed in detail and future perspectives of apolipoprotein research were discussed.