BOIN: An R Package for Designing Single-Agent and Drug-Combination Dose-Finding Trials Using Bayesian Optimal Interval Designs

BOIN: An R Package for Designing Single-Agent and Drug-Combination Dose-Finding Trials Using Bayesian Optimal Interval Designs

This article describes the R package BOIN, which implements a recently developed methodology for designing single-agent and drug-combination dose-finding clinical trials using Bayesian optimal interval designs (Liu and Yuan 2015; Yuan, Hess, Hilsenbeck, and Gilbert 2016). The BOIN designs are novel...

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Bibliographic Details
Main Authors: Fangrong Yan, Liangcai Zhang, Yanhong Zhou, Haitao Pan, Suyu Liu, Ying Yuan
Format: Article
Language:English
Published: Foundation for Open Access Statistics 2020-09-01
Series:Journal of Statistical Software
Subjects:
maximum tolerated dose
dose finding
phase i trials
model-assisted design
bayesian adaptive design
Online Access:https://www.jstatsoft.org/index.php/jss/article/view/2660

Internet

https://www.jstatsoft.org/index.php/jss/article/view/2660

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