Hypothermia ameliorates blast-related lifespan reduction of C. elegans
Abstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction...
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2018-07-01
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Online Access: | https://doi.org/10.1038/s41598-018-28910-z |
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doaj-897918e21d0d4e06ab4a6f8d802b27a42020-12-08T06:15:51ZengNature Publishing GroupScientific Reports2045-23222018-07-01811510.1038/s41598-018-28910-zHypothermia ameliorates blast-related lifespan reduction of C. elegansNicholas B. Angstman0Hans-Georg FrankChristoph Schmitz1Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, LMU MunichChair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, LMU MunichAbstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors. Hypothermia reduced the long term effect of shock wave exposure. Thus, we present an effective C. elegans model of long term effects of blast-related mild traumatic brain injury, as well as evidence of the merit of therapeutic hypothermia as a therapy option following blast exposure.https://doi.org/10.1038/s41598-018-28910-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz |
spellingShingle |
Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz Hypothermia ameliorates blast-related lifespan reduction of C. elegans Scientific Reports |
author_facet |
Nicholas B. Angstman Hans-Georg Frank Christoph Schmitz |
author_sort |
Nicholas B. Angstman |
title |
Hypothermia ameliorates blast-related lifespan reduction of C. elegans |
title_short |
Hypothermia ameliorates blast-related lifespan reduction of C. elegans |
title_full |
Hypothermia ameliorates blast-related lifespan reduction of C. elegans |
title_fullStr |
Hypothermia ameliorates blast-related lifespan reduction of C. elegans |
title_full_unstemmed |
Hypothermia ameliorates blast-related lifespan reduction of C. elegans |
title_sort |
hypothermia ameliorates blast-related lifespan reduction of c. elegans |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-07-01 |
description |
Abstract Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In a Caenorhabditis elegans model, we demonstrate a dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, we show that cavitation is a key injurious factor in the damaging shock wave component. Short and long lifespan C. elegans mutants demonstrated the interaction of genetic and environmental longevity-determining factors. Hypothermia reduced the long term effect of shock wave exposure. Thus, we present an effective C. elegans model of long term effects of blast-related mild traumatic brain injury, as well as evidence of the merit of therapeutic hypothermia as a therapy option following blast exposure. |
url |
https://doi.org/10.1038/s41598-018-28910-z |
work_keys_str_mv |
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