Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015
Objectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. Methods: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases dia...
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doaj-897f76e0a6b246bb9effdc6d0064b9a12020-11-24T21:25:17ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042017-01-01321364010.5001/omj.2017.07Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015Zied Gaifer0Ahmed Babiker1Dawar Rizavi2Department of Medicine, Sultan Qaboos University Hospital, Al-Khoud, OmanDepartment of Internal Medicine, Providence Hospital, Washington D.C, United States of AmericaDepartment of Medicine, Sultan Qaboos University Hospital, Al-Khoud, OmanObjectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. Methods: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. Results: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09−70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07−13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61−28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. Conclusions: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB.http://omjournal.org/articleDetails.aspx?coType=1&aId=1856TuberculosisDrug ResistantOman |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zied Gaifer Ahmed Babiker Dawar Rizavi |
spellingShingle |
Zied Gaifer Ahmed Babiker Dawar Rizavi Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 Oman Medical Journal Tuberculosis Drug Resistant Oman |
author_facet |
Zied Gaifer Ahmed Babiker Dawar Rizavi |
author_sort |
Zied Gaifer |
title |
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 |
title_short |
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 |
title_full |
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 |
title_fullStr |
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 |
title_full_unstemmed |
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006−2015 |
title_sort |
epidemiology of drug-resistant tuberculosis in a tertiary care center in oman, 2006−2015 |
publisher |
Oman Medical Specialty Board |
series |
Oman Medical Journal |
issn |
1999-768X 2070-5204 |
publishDate |
2017-01-01 |
description |
Objectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. Methods: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. Results: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09−70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07−13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61−28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. Conclusions: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB. |
topic |
Tuberculosis Drug Resistant Oman |
url |
http://omjournal.org/articleDetails.aspx?coType=1&aId=1856 |
work_keys_str_mv |
AT ziedgaifer epidemiologyofdrugresistanttuberculosisinatertiarycarecenterinoman20062015 AT ahmedbabiker epidemiologyofdrugresistanttuberculosisinatertiarycarecenterinoman20062015 AT dawarrizavi epidemiologyofdrugresistanttuberculosisinatertiarycarecenterinoman20062015 |
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1725983748784128000 |