The Role of Skin Barrier in the Pathogenesis of Food Allergy

The Role of Skin Barrier in the Pathogenesis of Food Allergy

Food allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically,...

Full description

Bibliographic Details
Main Authors: Neema Izadi, Minnelly Luu, Peck Y. Ong, Jonathan S. Tam
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Children
Subjects:
food allergy
skin barrier
allergic sensitization
filaggrin
Online Access:http://www.mdpi.com/2227-9067/2/3/382
id doaj-8983cf5b763e4a189ccd65bff5affad7
record_format Article
spelling doaj-8983cf5b763e4a189ccd65bff5affad72021-04-02T13:39:38ZengMDPI AGChildren2227-90672015-09-012338240210.3390/children2030382children2030382The Role of Skin Barrier in the Pathogenesis of Food AllergyNeema Izadi0Minnelly Luu1Peck Y. Ong2Jonathan S. Tam3Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USADepartment of Dermatology, Keck School of Medicine, University of Southern CaliforniaDivision of Clinical Immunology and Allergy, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern CaliforniaDivision of Clinical Immunology and Allergy, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern CaliforniaFood allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically, food sensitization was thought to occur through the gastrointestinal tract, but alternative routes of sensitization are being explored, specifically through the skin. Damaged skin barrier may play a crucial role in the development of food sensitization. Better understanding of how patients initially become sensitized may help lead to the development of a safe and effective treatment for food allergies or better prevention strategies.http://www.mdpi.com/2227-9067/2/3/382food allergyskin barrierallergic sensitizationfilaggrin
collection DOAJ
language English
format Article
sources DOAJ
author Neema Izadi
Minnelly Luu
Peck Y. Ong
Jonathan S. Tam
spellingShingle Neema Izadi
Minnelly Luu
Peck Y. Ong
Jonathan S. Tam
The Role of Skin Barrier in the Pathogenesis of Food Allergy
Children
food allergy
skin barrier
allergic sensitization
filaggrin
author_facet Neema Izadi
Minnelly Luu
Peck Y. Ong
Jonathan S. Tam
author_sort Neema Izadi
title The Role of Skin Barrier in the Pathogenesis of Food Allergy
title_short The Role of Skin Barrier in the Pathogenesis of Food Allergy
title_full The Role of Skin Barrier in the Pathogenesis of Food Allergy
title_fullStr The Role of Skin Barrier in the Pathogenesis of Food Allergy
title_full_unstemmed The Role of Skin Barrier in the Pathogenesis of Food Allergy
title_sort role of skin barrier in the pathogenesis of food allergy
publisher MDPI AG
series Children
issn 2227-9067
publishDate 2015-09-01
description Food allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically, food sensitization was thought to occur through the gastrointestinal tract, but alternative routes of sensitization are being explored, specifically through the skin. Damaged skin barrier may play a crucial role in the development of food sensitization. Better understanding of how patients initially become sensitized may help lead to the development of a safe and effective treatment for food allergies or better prevention strategies.
topic food allergy
skin barrier
allergic sensitization
filaggrin
url http://www.mdpi.com/2227-9067/2/3/382
work_keys_str_mv AT neemaizadi theroleofskinbarrierinthepathogenesisoffoodallergy
AT minnellyluu theroleofskinbarrierinthepathogenesisoffoodallergy
AT peckyong theroleofskinbarrierinthepathogenesisoffoodallergy
AT jonathanstam theroleofskinbarrierinthepathogenesisoffoodallergy
AT neemaizadi roleofskinbarrierinthepathogenesisoffoodallergy
AT minnellyluu roleofskinbarrierinthepathogenesisoffoodallergy
AT peckyong roleofskinbarrierinthepathogenesisoffoodallergy
AT jonathanstam roleofskinbarrierinthepathogenesisoffoodallergy
_version_ 1721564281744392192

Similar Items