The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades
BackgroundOver the past several decades, there has been a rapid worldwide increase in the prevalence of papillary thyroid cancer (PTC) as well as a number of changes in the clinicopathological characteristics of this disease. BRAFV600E, which is a mutation of the proto-oncogene BRAF, has become the...
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doaj-898a62f6615f4130b27cdf55cc527ea12020-11-24T23:39:51ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782014-12-0129450551310.3803/EnM.2014.29.4.50521212The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two DecadesA Ram HongJung Ah LimTae Hyuk KimHoon Sung ChoiWon Sang YooHye Sook MinJae Kyung WonKyu Eun LeeKyeong Cheon JungDo Joon ParkYoung Joo ParkBackgroundOver the past several decades, there has been a rapid worldwide increase in the prevalence of papillary thyroid cancer (PTC) as well as a number of changes in the clinicopathological characteristics of this disease. BRAFV600E, which is a mutation of the proto-oncogene BRAF, has become the most frequent genetic mutation associated with PTC, particularly in Korea. Thus, the present study investigated whether the prevalence of the BRAFV600E mutation has increased over the past two decades in the Korean population and whether various PTC-related clinicopathological characteristics have changed.MethodsThe present study included 2,624 patients who underwent a thyroidectomy for PTC during two preselected periods; 1995 to 2003 and 2009 to 2012. The BRAFV600E mutation status of each patient was confirmed using the polymerase chain reaction-restriction fragment length polymorphism method or by the direct sequencing of DNA.ResultsThe prevalence of the BRAFV600E mutation in Korean PTC patients increased from 62.2% to 73.7% (P=0.001) over the last two decades. Additionally, there was a greater degree of extrathyroidal extension (ETE) and lymph node metastasis in 2009 to 2012 patients with the BRAFV600E mutation and a higher frequency of thyroiditis and follicular variant-PTC in 2009 to 2012 patients with wild-type BRAF. However, only the frequency of ETE was significantly higher in 1995 to 2003 patients with the BRAFV600E mutation (P=0.047). Long-term recurrence rates during a 10-year median follow-up did not differ based on BRAFV600E mutation status.ConclusionThe BRAFV600E mutation rate in Korean PTC patients has been persistently high (approximately 70%) over the past two decades and continues to increase. The present findings demonstrate that BRAFV600E-positive PTC was associated with more aggressive clinicopathological features, especially in patients who were recently diagnosed, suggesting that BRAFV600E mutation status may be a useful prognostic factor for PTC in patients recently diagnosed with this disease.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-505.pdfThyroid cancer, papillaryBRAF mutationPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A Ram Hong Jung Ah Lim Tae Hyuk Kim Hoon Sung Choi Won Sang Yoo Hye Sook Min Jae Kyung Won Kyu Eun Lee Kyeong Cheon Jung Do Joon Park Young Joo Park |
spellingShingle |
A Ram Hong Jung Ah Lim Tae Hyuk Kim Hoon Sung Choi Won Sang Yoo Hye Sook Min Jae Kyung Won Kyu Eun Lee Kyeong Cheon Jung Do Joon Park Young Joo Park The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades Endocrinology and Metabolism Thyroid cancer, papillary BRAF mutation Prognosis |
author_facet |
A Ram Hong Jung Ah Lim Tae Hyuk Kim Hoon Sung Choi Won Sang Yoo Hye Sook Min Jae Kyung Won Kyu Eun Lee Kyeong Cheon Jung Do Joon Park Young Joo Park |
author_sort |
A Ram Hong |
title |
The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades |
title_short |
The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades |
title_full |
The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades |
title_fullStr |
The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades |
title_full_unstemmed |
The Frequency and Clinical Implications of the BRAF Mutation in Papillary Thyroid Cancer Patients in Korea Over the Past Two Decades |
title_sort |
frequency and clinical implications of the braf mutation in papillary thyroid cancer patients in korea over the past two decades |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2014-12-01 |
description |
BackgroundOver the past several decades, there has been a rapid worldwide increase in the prevalence of papillary thyroid cancer (PTC) as well as a number of changes in the clinicopathological characteristics of this disease. BRAFV600E, which is a mutation of the proto-oncogene BRAF, has become the most frequent genetic mutation associated with PTC, particularly in Korea. Thus, the present study investigated whether the prevalence of the BRAFV600E mutation has increased over the past two decades in the Korean population and whether various PTC-related clinicopathological characteristics have changed.MethodsThe present study included 2,624 patients who underwent a thyroidectomy for PTC during two preselected periods; 1995 to 2003 and 2009 to 2012. The BRAFV600E mutation status of each patient was confirmed using the polymerase chain reaction-restriction fragment length polymorphism method or by the direct sequencing of DNA.ResultsThe prevalence of the BRAFV600E mutation in Korean PTC patients increased from 62.2% to 73.7% (P=0.001) over the last two decades. Additionally, there was a greater degree of extrathyroidal extension (ETE) and lymph node metastasis in 2009 to 2012 patients with the BRAFV600E mutation and a higher frequency of thyroiditis and follicular variant-PTC in 2009 to 2012 patients with wild-type BRAF. However, only the frequency of ETE was significantly higher in 1995 to 2003 patients with the BRAFV600E mutation (P=0.047). Long-term recurrence rates during a 10-year median follow-up did not differ based on BRAFV600E mutation status.ConclusionThe BRAFV600E mutation rate in Korean PTC patients has been persistently high (approximately 70%) over the past two decades and continues to increase. The present findings demonstrate that BRAFV600E-positive PTC was associated with more aggressive clinicopathological features, especially in patients who were recently diagnosed, suggesting that BRAFV600E mutation status may be a useful prognostic factor for PTC in patients recently diagnosed with this disease. |
topic |
Thyroid cancer, papillary BRAF mutation Prognosis |
url |
http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-505.pdf |
work_keys_str_mv |
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