YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

Abstract Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between functionally distinct cell states dependent on EWS-FLI1 fluctuations. Whereas EWS-FLI1high cells proliferate, EWS-FLI1l...

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Main Authors: Lisa Bierbaumer, Anna M. Katschnig, Branka Radic-Sarikas, Maximilian O. Kauer, Jeffrey A. Petro, Sandra Högler, Elisabeth Gurnhofer, Gloria Pedot, Beat W. Schäfer, Raphaela Schwentner, Karin Mühlbacher, Florian Kromp, Dave N. T. Aryee, Lukas Kenner, Aykut Uren, Heinrich Kovar
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-020-00294-8

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