Sirtuins and Their Role in the Aging Eye (Review)
Visual impairment in elderly people is a serious problem that significantly affects the quality of life of millions people around the world. The magnitude of this problem is becoming increasingly apparent as the population ages and the number of older people increases. Age-related macular degenerati...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
Ophthalmology Publishing Group
2020-09-01
|
Series: | Oftalʹmologiâ |
Subjects: | |
Online Access: | https://www.ophthalmojournal.com/opht/article/view/1271 |
id |
doaj-89bc919f11784348bff5b9f7e87edfab |
---|---|
record_format |
Article |
spelling |
doaj-89bc919f11784348bff5b9f7e87edfab2021-07-29T08:55:29ZrusOphthalmology Publishing GroupOftalʹmologiâ 1816-50952020-09-0117333033510.18008/1816-5095-2020-3-330-335639Sirtuins and Their Role in the Aging Eye (Review)L. K. Moshetova0O. I. Abramova1K. I. Turkina2M. K. Nurbekov3O. P. Dmitrenko4I. N. Saburina5S. A. Kochergin6Russian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationThe Institute of General Pathology and PathophysiologyThe Institute of General Pathology and Pathophysiologyar and Personalized Medicine of Russian Medical Academy of Continuous Professional Education; The Institute of General Pathology and PathophysiologyRussian Medical Academy of Continuous Professional EducationVisual impairment in elderly people is a serious problem that significantly affects the quality of life of millions people around the world. The magnitude of this problem is becoming increasingly apparent as the population ages and the number of older people increases. Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide and the main cause of vision loss in people over 60 years. It is expected that AMD will affect about 288 million people by 2040. AMD is a multifactorial disease with a progressive course. The arised dystrophic changes in the retina cannot be reversed by any of the known treatment methods. A lot of research and effort has already been invested in identifying various biomarkers for predicting the incidence rate, identifying people at risk, finding out the pathogenetic mechanisms of this disease, and finding effective methods of treatment and prevention.Aging is the basis of pathological changes that occur during AMD. Aging biomarkers are measurable vital signs that qualitatively and quantitatively change with the age of the body. DNA methylation is a molecular mechanism that is a potential biomarker of aging. Sirtuins indirectly participate in this process, regulating the activity of the DNMT1 enzyme. The article discusses current knowledge of the mechanisms underlying the action of sirtuins (Sirtuins / SIRT), with an emphasis on SIRT1. Analysis of the pathophysiological action of sirtuins can affect the prevention and treatment of pathological eye changes associated with AMD. The article provides literature sources containing the results of studies of the effect of SIRT1 as a marker of aging in body tissues. SIRT1 is an attractive candidate for developing therapeutic strategies preventing early eye aging, in particular, age-associated diseases such as AMD The impact on the genetic mechanisms of this disease is a promising direction in treatment.https://www.ophthalmojournal.com/opht/article/view/1271sirtuinsaging genesage-related macular degenerationsirt1age associated diseases |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
L. K. Moshetova O. I. Abramova K. I. Turkina M. K. Nurbekov O. P. Dmitrenko I. N. Saburina S. A. Kochergin |
spellingShingle |
L. K. Moshetova O. I. Abramova K. I. Turkina M. K. Nurbekov O. P. Dmitrenko I. N. Saburina S. A. Kochergin Sirtuins and Their Role in the Aging Eye (Review) Oftalʹmologiâ sirtuins aging genes age-related macular degeneration sirt1 age associated diseases |
author_facet |
L. K. Moshetova O. I. Abramova K. I. Turkina M. K. Nurbekov O. P. Dmitrenko I. N. Saburina S. A. Kochergin |
author_sort |
L. K. Moshetova |
title |
Sirtuins and Their Role in the Aging Eye (Review) |
title_short |
Sirtuins and Their Role in the Aging Eye (Review) |
title_full |
Sirtuins and Their Role in the Aging Eye (Review) |
title_fullStr |
Sirtuins and Their Role in the Aging Eye (Review) |
title_full_unstemmed |
Sirtuins and Their Role in the Aging Eye (Review) |
title_sort |
sirtuins and their role in the aging eye (review) |
publisher |
Ophthalmology Publishing Group |
series |
Oftalʹmologiâ |
issn |
1816-5095 |
publishDate |
2020-09-01 |
description |
Visual impairment in elderly people is a serious problem that significantly affects the quality of life of millions people around the world. The magnitude of this problem is becoming increasingly apparent as the population ages and the number of older people increases. Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide and the main cause of vision loss in people over 60 years. It is expected that AMD will affect about 288 million people by 2040. AMD is a multifactorial disease with a progressive course. The arised dystrophic changes in the retina cannot be reversed by any of the known treatment methods. A lot of research and effort has already been invested in identifying various biomarkers for predicting the incidence rate, identifying people at risk, finding out the pathogenetic mechanisms of this disease, and finding effective methods of treatment and prevention.Aging is the basis of pathological changes that occur during AMD. Aging biomarkers are measurable vital signs that qualitatively and quantitatively change with the age of the body. DNA methylation is a molecular mechanism that is a potential biomarker of aging. Sirtuins indirectly participate in this process, regulating the activity of the DNMT1 enzyme. The article discusses current knowledge of the mechanisms underlying the action of sirtuins (Sirtuins / SIRT), with an emphasis on SIRT1. Analysis of the pathophysiological action of sirtuins can affect the prevention and treatment of pathological eye changes associated with AMD. The article provides literature sources containing the results of studies of the effect of SIRT1 as a marker of aging in body tissues. SIRT1 is an attractive candidate for developing therapeutic strategies preventing early eye aging, in particular, age-associated diseases such as AMD The impact on the genetic mechanisms of this disease is a promising direction in treatment. |
topic |
sirtuins aging genes age-related macular degeneration sirt1 age associated diseases |
url |
https://www.ophthalmojournal.com/opht/article/view/1271 |
work_keys_str_mv |
AT lkmoshetova sirtuinsandtheirroleintheagingeyereview AT oiabramova sirtuinsandtheirroleintheagingeyereview AT kiturkina sirtuinsandtheirroleintheagingeyereview AT mknurbekov sirtuinsandtheirroleintheagingeyereview AT opdmitrenko sirtuinsandtheirroleintheagingeyereview AT insaburina sirtuinsandtheirroleintheagingeyereview AT sakochergin sirtuinsandtheirroleintheagingeyereview |
_version_ |
1721250951583498240 |