Indicators of response to exercise training: a systematic review and meta-analysis
Background Means-based analysis of maximal rate of oxygen consumption (VO2max) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training (RET) for improving cardiorespiratory fitness and w...
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doaj-89becf6f414b45638db0978e5153f7b52021-08-07T16:33:21ZengBMJ Publishing GroupBMJ Open2044-60552021-07-0111710.1136/bmjopen-2020-044676Indicators of response to exercise training: a systematic review and meta-analysisIskandar Idris0Brett Doleman1Philip J Atherton2Arash Ardavani3Hariz Aziz4Bethan E Phillips5Imran Ramzan6Boshra Mozaffar7Division of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKDivision of Graduate Entry Medicine, School of Medicine, University of Nottingham, Derby, UKBackground Means-based analysis of maximal rate of oxygen consumption (VO2max) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training (RET) for improving cardiorespiratory fitness and whole-body health. However, considerable heterogeneity exists in the interindividual variability response to the same or different training modalities.Objectives We performed a systematic review and meta-analysis to investigate exercise response rates in the context of VO2max: (1) in each training modality (END, HIIT and RET) versus controls, (2) in END versus either HIIT or RET and (3) exercise response rates as measured by VO2max versus other indicators of positive exercise response in each exercise modality.Methods Three databases (EMBASE, MEDLINE, CENTRAL) and additional sources were searched. Both individual response rate and population average data were incorporated through continuous data, respectively. Of 3268 identified manuscripts, a total of 29 studies were suitable for qualitative synthesis and a further 22 for quantitative. Stratification based on intervention duration (less than 12 weeks; more than or equal to 12 weeks) was undertaken.Results A total of 62 data points were procured. Both END and HIIT training exhibited differential improvements in VO2max based on intervention duration. VO2max did not adequately differentiate between END and HIIT, irrespective of intervention length. Although none of the other exercise response indicators achieved statistical significance, LT and HRrest demonstrated common trajectories in pooled and separate analyses between modalities. RET data were highly limited. Heterogeneity was ubiquitous across all analyses.Conclusions The potential for LT and HRrest as indicators of exercise response requires further elucidation, in addition to the exploration of interventional and intrinsic sources of heterogeneity.https://bmjopen.bmj.com/content/11/7/e044676.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iskandar Idris Brett Doleman Philip J Atherton Arash Ardavani Hariz Aziz Bethan E Phillips Imran Ramzan Boshra Mozaffar |
spellingShingle |
Iskandar Idris Brett Doleman Philip J Atherton Arash Ardavani Hariz Aziz Bethan E Phillips Imran Ramzan Boshra Mozaffar Indicators of response to exercise training: a systematic review and meta-analysis BMJ Open |
author_facet |
Iskandar Idris Brett Doleman Philip J Atherton Arash Ardavani Hariz Aziz Bethan E Phillips Imran Ramzan Boshra Mozaffar |
author_sort |
Iskandar Idris |
title |
Indicators of response to exercise training: a systematic review and meta-analysis |
title_short |
Indicators of response to exercise training: a systematic review and meta-analysis |
title_full |
Indicators of response to exercise training: a systematic review and meta-analysis |
title_fullStr |
Indicators of response to exercise training: a systematic review and meta-analysis |
title_full_unstemmed |
Indicators of response to exercise training: a systematic review and meta-analysis |
title_sort |
indicators of response to exercise training: a systematic review and meta-analysis |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-07-01 |
description |
Background Means-based analysis of maximal rate of oxygen consumption (VO2max) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training (RET) for improving cardiorespiratory fitness and whole-body health. However, considerable heterogeneity exists in the interindividual variability response to the same or different training modalities.Objectives We performed a systematic review and meta-analysis to investigate exercise response rates in the context of VO2max: (1) in each training modality (END, HIIT and RET) versus controls, (2) in END versus either HIIT or RET and (3) exercise response rates as measured by VO2max versus other indicators of positive exercise response in each exercise modality.Methods Three databases (EMBASE, MEDLINE, CENTRAL) and additional sources were searched. Both individual response rate and population average data were incorporated through continuous data, respectively. Of 3268 identified manuscripts, a total of 29 studies were suitable for qualitative synthesis and a further 22 for quantitative. Stratification based on intervention duration (less than 12 weeks; more than or equal to 12 weeks) was undertaken.Results A total of 62 data points were procured. Both END and HIIT training exhibited differential improvements in VO2max based on intervention duration. VO2max did not adequately differentiate between END and HIIT, irrespective of intervention length. Although none of the other exercise response indicators achieved statistical significance, LT and HRrest demonstrated common trajectories in pooled and separate analyses between modalities. RET data were highly limited. Heterogeneity was ubiquitous across all analyses.Conclusions The potential for LT and HRrest as indicators of exercise response requires further elucidation, in addition to the exploration of interventional and intrinsic sources of heterogeneity. |
url |
https://bmjopen.bmj.com/content/11/7/e044676.full |
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