Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes

Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes

Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood....

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Bibliographic Details
Main Authors: Peter Edward Jensen, Zemin eZhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
Autoreactive T cells
HLA-DM
negative selection
HLA-DQ
invariant chain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/full
Description
Summary:Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.
ISSN:1664-3224

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