Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes

Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes

Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood....

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Bibliographic Details
Main Authors: Peter Edward Jensen, Zemin eZhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
Autoreactive T cells
HLA-DM
negative selection
HLA-DQ
invariant chain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/full
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spelling doaj-89c8710fa25f4ca5b0a1ba238cc0d8ac2020-11-24T23:02:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-08-01410.3389/fimmu.2013.0026261726Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetesPeter Edward Jensen0Zemin eZhou1University of UtahUniversity of UtahAutoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/fulltype 1 diabetesAutoreactive T cellsHLA-DMnegative selectionHLA-DQinvariant chain
collection DOAJ
language English
format Article
sources DOAJ
author Peter Edward Jensen
Zemin eZhou
spellingShingle Peter Edward Jensen
Zemin eZhou
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
Frontiers in Immunology
type 1 diabetes
Autoreactive T cells
HLA-DM
negative selection
HLA-DQ
invariant chain
author_facet Peter Edward Jensen
Zemin eZhou
author_sort Peter Edward Jensen
title Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
title_short Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
title_full Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
title_fullStr Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
title_full_unstemmed Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
title_sort structural characteristics of hla-dq that may impact dm editing and susceptibility to type-1 diabetes
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2013-08-01
description Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.
topic type 1 diabetes
Autoreactive T cells
HLA-DM
negative selection
HLA-DQ
invariant chain
url http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/full
work_keys_str_mv AT peteredwardjensen structuralcharacteristicsofhladqthatmayimpactdmeditingandsusceptibilitytotype1diabetes
AT zeminezhou structuralcharacteristicsofhladqthatmayimpactdmeditingandsusceptibilitytotype1diabetes
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