Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes
Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood....
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doaj-89c8710fa25f4ca5b0a1ba238cc0d8ac2020-11-24T23:02:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-08-01410.3389/fimmu.2013.0026261726Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetesPeter Edward Jensen0Zemin eZhou1University of UtahUniversity of UtahAutoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/fulltype 1 diabetesAutoreactive T cellsHLA-DMnegative selectionHLA-DQinvariant chain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peter Edward Jensen Zemin eZhou |
spellingShingle |
Peter Edward Jensen Zemin eZhou Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes Frontiers in Immunology type 1 diabetes Autoreactive T cells HLA-DM negative selection HLA-DQ invariant chain |
author_facet |
Peter Edward Jensen Zemin eZhou |
author_sort |
Peter Edward Jensen |
title |
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes |
title_short |
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes |
title_full |
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes |
title_fullStr |
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes |
title_full_unstemmed |
Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to Type-1 diabetes |
title_sort |
structural characteristics of hla-dq that may impact dm editing and susceptibility to type-1 diabetes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2013-08-01 |
description |
Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D. |
topic |
type 1 diabetes Autoreactive T cells HLA-DM negative selection HLA-DQ invariant chain |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00262/full |
work_keys_str_mv |
AT peteredwardjensen structuralcharacteristicsofhladqthatmayimpactdmeditingandsusceptibilitytotype1diabetes AT zeminezhou structuralcharacteristicsofhladqthatmayimpactdmeditingandsusceptibilitytotype1diabetes |
_version_ |
1725636068065148928 |