Approaches to the Development of a Low-dose Naltrexone Preparation in the Form of a Nasal Spray (Review)

Approaches to the Development of a Low-dose Naltrexone Preparation in the Form of a Nasal Spray (Review)

Introduction. Naltrexone hydrochloride belongs to µ-opioid receptor antagonists and is widely used in the treatment of alcohol and drug addiction at an oral dose of 50 mg/day. It is also a blocker of other receptors – opioid growth factor and Toll-like factor, which is especially evident at doses of...

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Bibliographic Details
Main Authors: Yu. M. Domnina, V. V. Suslov, S. A. Kedik, P. O. Volkova
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2021-02-01
Series:Разработка и регистрация лекарственных средств
Subjects:
low-dose naltrexone
mechanism of action
intranasal administration
Online Access:https://www.pharmjournal.ru/jour/article/view/852

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