A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia

A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a GAA repeat expansion mutation within intron 1 of the FXN gene, resulting in reduced levels of frataxin protein. We have previously reported the generation of human FXN yeast artificial chromosome (YAC) transg...

Full description

Bibliographic Details
Main Authors: Sara Anjomani Virmouni, Vahid Ezzatizadeh, Chiranjeevi Sandi, Madhavi Sandi, Sahar Al-Mahdawi, Yogesh Chutake, Mark A. Pook
Format: Article
Language:English
Published: The Company of Biologists 2015-03-01
Series:Disease Models & Mechanisms
Subjects:
GAA repeat
Friedreich’s ataxia
FRDA
YG8sR
Mouse model
Online Access:http://dmm.biologists.org/content/8/3/225

Internet

http://dmm.biologists.org/content/8/3/225

Similar Items