Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups
The Fusarium mycotoxin deoxynivalenol (DON) and its modified forms are present in most samples of grain and grain-based products. Due to the widespread presence of DON in these highly consumed food commodities, nearly all individuals are exposed to DON. Previous estimates of the dietary DON intake i...
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doaj-89cf76aabfaf4429aa98427241563c182021-10-01T04:46:10ZengElsevierEnvironment International0160-41202021-12-01157106804Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groupsGunnar Sundstøl Eriksen0Helle K. Knutsen1Morten Sandvik2Anne-Lise Brantsæter3Toxinology Research Group, Norwegian Veterinary Institute, Oslo, Norway; Corresponding author.Department of Environmental Health, Norwegian Institute of Public Health, Oslo, NorwayToxinology Research Group, Norwegian Veterinary Institute, Oslo, NorwayDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, NorwayThe Fusarium mycotoxin deoxynivalenol (DON) and its modified forms are present in most samples of grain and grain-based products. Due to the widespread presence of DON in these highly consumed food commodities, nearly all individuals are exposed to DON. Previous estimates of the dietary DON intake in Norway indicated that children’s dietary intake is close to or exceed the TDI of 1 µg/kg bw/day for the sum of DON and three modified forms. One aim of the current study was to determine whether the concentrations of DON in morning urine differ between population groups like men, women, children, vegetarians, and pregnant women. An additional aim was to compare a set of models for estimating the dietary intake of DON based on urinary DON concentrations and also compare these models with DON-intakes estimated using food consumption data. DON and metabolites were detected in the morning urine from 256 out of 257 individuals and with concentrations in similar range as reported from other countries. Children have higher urinary DON-concentration than adults and elderly. The urinary DON-concentration in pregnant women and vegetarians did not differ from other adults. The estimated intake of DON was higher for children than for other age groups on a body weight basis. The correlations between different models for estimating DON-intake based on urinary concentration as well as based on individual food consumption were good (0.79–0.99), but with some outliers. We conclude that Norwegians are exposed to DON in the same range as reported from other countries and that children have a higher exposure than adults. Furthermore, we conclude that intake estimates based on urinary DON concentration is a useful tool for evaluation of the exposure at population level, but due to outliers, the estimates for individuals are uncertain. There are also uncertainties in intake estimates both from food consumption and from urinary DON concentration, and we could not conclude on which approach provides the most accurate exposure estimate.http://www.sciencedirect.com/science/article/pii/S0160412021004293DeoxynivalenolDietary intakeMorning urineExposure estimates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gunnar Sundstøl Eriksen Helle K. Knutsen Morten Sandvik Anne-Lise Brantsæter |
spellingShingle |
Gunnar Sundstøl Eriksen Helle K. Knutsen Morten Sandvik Anne-Lise Brantsæter Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups Environment International Deoxynivalenol Dietary intake Morning urine Exposure estimates |
author_facet |
Gunnar Sundstøl Eriksen Helle K. Knutsen Morten Sandvik Anne-Lise Brantsæter |
author_sort |
Gunnar Sundstøl Eriksen |
title |
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
title_short |
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
title_full |
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
title_fullStr |
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
title_full_unstemmed |
Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
title_sort |
urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-12-01 |
description |
The Fusarium mycotoxin deoxynivalenol (DON) and its modified forms are present in most samples of grain and grain-based products. Due to the widespread presence of DON in these highly consumed food commodities, nearly all individuals are exposed to DON. Previous estimates of the dietary DON intake in Norway indicated that children’s dietary intake is close to or exceed the TDI of 1 µg/kg bw/day for the sum of DON and three modified forms. One aim of the current study was to determine whether the concentrations of DON in morning urine differ between population groups like men, women, children, vegetarians, and pregnant women. An additional aim was to compare a set of models for estimating the dietary intake of DON based on urinary DON concentrations and also compare these models with DON-intakes estimated using food consumption data. DON and metabolites were detected in the morning urine from 256 out of 257 individuals and with concentrations in similar range as reported from other countries. Children have higher urinary DON-concentration than adults and elderly. The urinary DON-concentration in pregnant women and vegetarians did not differ from other adults. The estimated intake of DON was higher for children than for other age groups on a body weight basis. The correlations between different models for estimating DON-intake based on urinary concentration as well as based on individual food consumption were good (0.79–0.99), but with some outliers. We conclude that Norwegians are exposed to DON in the same range as reported from other countries and that children have a higher exposure than adults. Furthermore, we conclude that intake estimates based on urinary DON concentration is a useful tool for evaluation of the exposure at population level, but due to outliers, the estimates for individuals are uncertain. There are also uncertainties in intake estimates both from food consumption and from urinary DON concentration, and we could not conclude on which approach provides the most accurate exposure estimate. |
topic |
Deoxynivalenol Dietary intake Morning urine Exposure estimates |
url |
http://www.sciencedirect.com/science/article/pii/S0160412021004293 |
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