Churg-Strauss Syndrome following PTU Treatment
Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haem...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2009-01-01
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| Series: | International Journal of Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2009/504105 |
| Summary: | Propylthiouracil (PTU) is a frequently prescribed drug in the treatment
of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially
serious side effects including vasculitis. PTU-related vasculitides can present as
haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific
symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement is
seldom observed. We present a 49-year-old female with Graves' disease and
asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU. A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected. Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms. |
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| ISSN: | 1687-9260 1687-9279 |