Churg-Strauss Syndrome following PTU Treatment

Churg-Strauss Syndrome following PTU Treatment

Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haem...

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Main Authors: R. A. M. Quax, A. J. G. Swaak, M. G. A. Baggen
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:International Journal of Rheumatology
Online Access:http://dx.doi.org/10.1155/2009/504105
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spelling doaj-89cff1d0ba034ca8b4d077a85222353e2020-11-25T00:32:51ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792009-01-01200910.1155/2009/504105504105Churg-Strauss Syndrome following PTU TreatmentR. A. M. Quax0A. J. G. Swaak1M. G. A. Baggen2Section of Endocrinology, Department of Internal Medicine, Erasmus Medical Centre Rotterdam, 3000 CA Rotterdam, The NetherlandsDepartment of Rheumatology, Ikazia Hospital, 3083 AN Rotterdam, The NetherlandsDepartment of Internal Medicine, Ikazia Hospital, 3083 AN Rotterdam, The NetherlandsPropylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement is seldom observed. We present a 49-year-old female with Graves' disease and asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU. A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected. Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms.http://dx.doi.org/10.1155/2009/504105
collection DOAJ
language English
format Article
sources DOAJ
author R. A. M. Quax
A. J. G. Swaak
M. G. A. Baggen
spellingShingle R. A. M. Quax
A. J. G. Swaak
M. G. A. Baggen
Churg-Strauss Syndrome following PTU Treatment
International Journal of Rheumatology
author_facet R. A. M. Quax
A. J. G. Swaak
M. G. A. Baggen
author_sort R. A. M. Quax
title Churg-Strauss Syndrome following PTU Treatment
title_short Churg-Strauss Syndrome following PTU Treatment
title_full Churg-Strauss Syndrome following PTU Treatment
title_fullStr Churg-Strauss Syndrome following PTU Treatment
title_full_unstemmed Churg-Strauss Syndrome following PTU Treatment
title_sort churg-strauss syndrome following ptu treatment
publisher Hindawi Limited
series International Journal of Rheumatology
issn 1687-9260
1687-9279
publishDate 2009-01-01
description Propylthiouracil (PTU) is a frequently prescribed drug in the treatment of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially serious side effects including vasculitis. PTU-related vasculitides can present as haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement is seldom observed. We present a 49-year-old female with Graves' disease and asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU. A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected. Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms.
url http://dx.doi.org/10.1155/2009/504105
work_keys_str_mv AT ramquax churgstrausssyndromefollowingptutreatment
AT ajgswaak churgstrausssyndromefollowingptutreatment
AT mgabaggen churgstrausssyndromefollowingptutreatment
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