Use of Permanent Wall-Deficient Cells as a System for the Discovery of New-to-Nature Metabolites

Use of Permanent Wall-Deficient Cells as a System for the Discovery of New-to-Nature Metabolites

Filamentous actinobacteria are widely used as microbial cell factories to produce valuable secondary metabolites, including the vast majority of clinically relevant antimicrobial compounds. Secondary metabolites are typically encoded by large biosynthetic gene clusters, which allow for a modular app...

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Bibliographic Details
Main Authors: Shraddha Shitut, Güniz Özer Bergman, Alexander Kros, Daniel E. Rozen, Dennis Claessen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Microorganisms
Subjects:
secondary metabolites
actinomycetes
protoplast fusion
novel compound discovery
cell wall-deficiency
heteroploidy
Online Access:https://www.mdpi.com/2076-2607/8/12/1897

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