GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
Recent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict the degree of stimulus-induced activity in the same region. These studies have used the presentation of discrete visual stimulus; the change from closed eyes to open also represents a simple visual stim...
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2012-12-01
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doaj-89dd76c403ba47c2a4497662ec6e79862020-11-25T02:54:26ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612012-12-01610.3389/fnhum.2012.0033733238GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulationPengmin eQin0Niall W Duncan1Niall W Duncan2Christine eWiebking3Christine eWiebking4Paul eGravel5oliver elyttelton6Dave eHayes7Jeroen eVerhaeghe8Alexey eKostikov9Ralf eSchirrmacher10Andrew J Reader11Georg eNorthoff12Univeristy of Ottawa Institute of Mental Health ResearchUniveristy of Ottawa Institute of Mental Health ResearchCarleton UniversityUniveristy of Ottawa Institute of Mental Health ResearchFreie Universität BerlinMcGill UniversityUniveristy of Ottawa Institute of Mental Health ResearchUniveristy of Ottawa Institute of Mental Health ResearchMcGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityUniveristy of Ottawa Institute of Mental Health ResearchRecent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict the degree of stimulus-induced activity in the same region. These studies have used the presentation of discrete visual stimulus; the change from closed eyes to open also represents a simple visual stimulus, however, and has been shown to induce changes in local brain activity and in functional connectivity between regions. We thus aimed to investigate the role of the GABA system, specifically GABAA receptors, in the changes in brain activity between the eyes closed (EC) and eyes open (EO) state in order to provide detail at the receptor level to complement previous studies of GABA concentrations. We conducted an fMRI study involving two different modes of the change from EC to EO: An EO and EC block design, allowing the modelling of the haemodynamic response, followed by longer periods of EC and EO to allow the measuring of functional connectivity. The same subjects also underwent [18F]Flumazenil PET measure GABAA receptor binding potentials. It was demonstrated that the local-to-global ratio of GABAA receptor binding potential in the visual cortex predicted the degree of changes in neural activity from EC to EO. This same relationship was also shown in the auditory cortex. Furthermore, the local-to-global ratio of GABAA receptor binding potential in the visual cortex also predicts the change of functional connectivity between visual and auditory cortex from EC to EO. These findings contribute to our understanding of the role of GABAA receptors in stimulus-induced neural activity in local regions and in inter-regional functional connectivity.http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00337/fullFlumazenilPETfunctional connectivityresting stateGABAA receptoreyes open |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengmin eQin Niall W Duncan Niall W Duncan Christine eWiebking Christine eWiebking Paul eGravel oliver elyttelton Dave eHayes Jeroen eVerhaeghe Alexey eKostikov Ralf eSchirrmacher Andrew J Reader Georg eNorthoff |
spellingShingle |
Pengmin eQin Niall W Duncan Niall W Duncan Christine eWiebking Christine eWiebking Paul eGravel oliver elyttelton Dave eHayes Jeroen eVerhaeghe Alexey eKostikov Ralf eSchirrmacher Andrew J Reader Georg eNorthoff GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation Frontiers in Human Neuroscience Flumazenil PET functional connectivity resting state GABAA receptor eyes open |
author_facet |
Pengmin eQin Niall W Duncan Niall W Duncan Christine eWiebking Christine eWiebking Paul eGravel oliver elyttelton Dave eHayes Jeroen eVerhaeghe Alexey eKostikov Ralf eSchirrmacher Andrew J Reader Georg eNorthoff |
author_sort |
Pengmin eQin |
title |
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
title_short |
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
title_full |
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
title_fullStr |
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
title_full_unstemmed |
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
title_sort |
gabaa receptors in visual and auditory cortex and neural activity changes during basic visual stimulation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2012-12-01 |
description |
Recent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict the degree of stimulus-induced activity in the same region. These studies have used the presentation of discrete visual stimulus; the change from closed eyes to open also represents a simple visual stimulus, however, and has been shown to induce changes in local brain activity and in functional connectivity between regions. We thus aimed to investigate the role of the GABA system, specifically GABAA receptors, in the changes in brain activity between the eyes closed (EC) and eyes open (EO) state in order to provide detail at the receptor level to complement previous studies of GABA concentrations. We conducted an fMRI study involving two different modes of the change from EC to EO: An EO and EC block design, allowing the modelling of the haemodynamic response, followed by longer periods of EC and EO to allow the measuring of functional connectivity. The same subjects also underwent [18F]Flumazenil PET measure GABAA receptor binding potentials. It was demonstrated that the local-to-global ratio of GABAA receptor binding potential in the visual cortex predicted the degree of changes in neural activity from EC to EO. This same relationship was also shown in the auditory cortex. Furthermore, the local-to-global ratio of GABAA receptor binding potential in the visual cortex also predicts the change of functional connectivity between visual and auditory cortex from EC to EO. These findings contribute to our understanding of the role of GABAA receptors in stimulus-induced neural activity in local regions and in inter-regional functional connectivity. |
topic |
Flumazenil PET functional connectivity resting state GABAA receptor eyes open |
url |
http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00337/full |
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