SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell inv...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09676-y |
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doaj-89df65835066448cbf1f8b48e72f32982021-05-11T12:34:46ZengNature Publishing GroupNature Communications2041-17232019-05-0110111510.1038/s41467-019-09676-ySREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancerYlenia Perone0Aaron J. Farrugia1Alba Rodríguez-Meira2Balázs Győrffy3Charlotte Ion4Andrea Uggetti5Antonios Chronopoulos6Pasquale Marrazzo7Monica Faronato8Sami Shousha9Claire Davies10Jennifer H. Steel11Naina Patel12Armando del Rio Hernandez13Charles Coombes14Giancarlo Pruneri15Adrian Lim16Fernando Calvo17Luca Magnani18Department of Surgery and Cancer, Imperial College LondonDivision of Cancer Biology, Tumour Microenvironment Team, Institute of Cancer ResearchDepartment of Surgery and Cancer, Imperial College LondonMTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of SciencesDepartment of Surgery and Cancer, Imperial College LondonEuropean Institute of OncologyFaculty of Engineering, Department of Bioengineering, Imperial College LondonDepartment for Life Quality Studies, Alma Mater Studiorum, University of BolognaDepartment of Chemistry, Imperial College LondonHistopathology Department, Imperial College London, Charing Cross Hospital NHS TrustECMC Imperial College. Department of Surgery and Cancer, Imperial College LondonECMC Imperial College. Department of Surgery and Cancer, Imperial College LondonECMC Imperial College. Department of Surgery and Cancer, Imperial College LondonFaculty of Engineering, Department of Bioengineering, Imperial College LondonDepartment of Surgery and Cancer, Imperial College LondonPathology Department, Fondazione IRCCS Istituto Nazionale Tumori and University of Milan, School of MedicineDepartment of Surgery and Cancer, Imperial College LondonDivision of Cancer Biology, Tumour Microenvironment Team, Institute of Cancer ResearchDepartment of Surgery and Cancer, Imperial College LondonERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion.https://doi.org/10.1038/s41467-019-09676-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ylenia Perone Aaron J. Farrugia Alba Rodríguez-Meira Balázs Győrffy Charlotte Ion Andrea Uggetti Antonios Chronopoulos Pasquale Marrazzo Monica Faronato Sami Shousha Claire Davies Jennifer H. Steel Naina Patel Armando del Rio Hernandez Charles Coombes Giancarlo Pruneri Adrian Lim Fernando Calvo Luca Magnani |
| spellingShingle |
Ylenia Perone Aaron J. Farrugia Alba Rodríguez-Meira Balázs Győrffy Charlotte Ion Andrea Uggetti Antonios Chronopoulos Pasquale Marrazzo Monica Faronato Sami Shousha Claire Davies Jennifer H. Steel Naina Patel Armando del Rio Hernandez Charles Coombes Giancarlo Pruneri Adrian Lim Fernando Calvo Luca Magnani SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer Nature Communications |
| author_facet |
Ylenia Perone Aaron J. Farrugia Alba Rodríguez-Meira Balázs Győrffy Charlotte Ion Andrea Uggetti Antonios Chronopoulos Pasquale Marrazzo Monica Faronato Sami Shousha Claire Davies Jennifer H. Steel Naina Patel Armando del Rio Hernandez Charles Coombes Giancarlo Pruneri Adrian Lim Fernando Calvo Luca Magnani |
| author_sort |
Ylenia Perone |
| title |
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer |
| title_short |
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer |
| title_full |
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer |
| title_fullStr |
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer |
| title_full_unstemmed |
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer |
| title_sort |
srebp1 drives keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant erα breast cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-05-01 |
| description |
ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion. |
| url |
https://doi.org/10.1038/s41467-019-09676-y |
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