The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis
The aim of this study was to analyze selected indicators of oxidative stress. The study subjects consisted of 42 women with Hashimoto’s disease and a control group of 30 healthy women. The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS)...
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doaj-89e11acc245a40928084c9610aa645602021-08-06T15:22:44ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-07-01187805780510.3390/ijerph18157805The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s ThyroiditisJoanna Szczepanik0Tomasz Podgórski1Katarzyna Domaszewska2Faculty of Health Sciences, School of Socio-Economics in Sroda Wielkopolska, 63-000 Sroda Wielkopolska, PolandDepartment of Physiology and Biochemistry, Poznan University of Physical Education, 61-871 Poznan, PolandFaculty of Health Sciences, Calisia University, 62-800 Kalisz, PolandThe aim of this study was to analyze selected indicators of oxidative stress. The study subjects consisted of 42 women with Hashimoto’s disease and a control group of 30 healthy women. The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS) and the total antioxidative potential by the Ferric Reducing Ability of Plasma (FRAP) method. In addition, an assessment of concentrations of thiobarbituric acid reactive substances (TBARS) and total phenolics was carried out. Our research showed a significant difference in TBARS concentration (<i>p</i> < 0.0001 (ES: 0.92)) without significant differences in Zn, Cu, FRAP and total phenolics concentrations. Analysis of the correlation of the obtained results of biochemical tests for both groups showed a highly significant dependence of FRAP and total phenolics concentration in the blood of the examined women (<i>r</i> = 0.5283, <i>p</i> = 0.0003). The obtained results indicate no differences in Cu, Zn, and FRAP concentrations in the blood between two analyzed groups and a significantly higher concentration of TBARS in Hashimoto’s thyroiditis women. The concentration of total phenolics significantly influences the value of the FRAP.https://www.mdpi.com/1660-4601/18/15/7805Hashimoto’s diseaseoxidative stressTBARSzinccopper |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Szczepanik Tomasz Podgórski Katarzyna Domaszewska |
spellingShingle |
Joanna Szczepanik Tomasz Podgórski Katarzyna Domaszewska The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis International Journal of Environmental Research and Public Health Hashimoto’s disease oxidative stress TBARS zinc copper |
author_facet |
Joanna Szczepanik Tomasz Podgórski Katarzyna Domaszewska |
author_sort |
Joanna Szczepanik |
title |
The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis |
title_short |
The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis |
title_full |
The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis |
title_fullStr |
The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis |
title_full_unstemmed |
The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis |
title_sort |
level of zinc, copper and antioxidant status in the blood serum of women with hashimoto’s thyroiditis |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-07-01 |
description |
The aim of this study was to analyze selected indicators of oxidative stress. The study subjects consisted of 42 women with Hashimoto’s disease and a control group of 30 healthy women. The concentration of zinc (Zn) and copper (Cu) in the serum was determined by Atomic Absorption Spectrometry (AAS) and the total antioxidative potential by the Ferric Reducing Ability of Plasma (FRAP) method. In addition, an assessment of concentrations of thiobarbituric acid reactive substances (TBARS) and total phenolics was carried out. Our research showed a significant difference in TBARS concentration (<i>p</i> < 0.0001 (ES: 0.92)) without significant differences in Zn, Cu, FRAP and total phenolics concentrations. Analysis of the correlation of the obtained results of biochemical tests for both groups showed a highly significant dependence of FRAP and total phenolics concentration in the blood of the examined women (<i>r</i> = 0.5283, <i>p</i> = 0.0003). The obtained results indicate no differences in Cu, Zn, and FRAP concentrations in the blood between two analyzed groups and a significantly higher concentration of TBARS in Hashimoto’s thyroiditis women. The concentration of total phenolics significantly influences the value of the FRAP. |
topic |
Hashimoto’s disease oxidative stress TBARS zinc copper |
url |
https://www.mdpi.com/1660-4601/18/15/7805 |
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