Sildenafil in Infants and Children
Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this treatment, and its success in treating PAH has led to its widespread...
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doaj-89e537a94f174fe1bff287248e5513df2021-04-02T16:13:50ZengMDPI AGChildren2227-90672017-07-01476010.3390/children4070060children4070060Sildenafil in Infants and ChildrenLarisa Simonca0Robert Tulloh1Department of Congenital Heart Disease, Bristol Royal Hospital for Children, Bristol BS2 8BJ, UKDepartment of Congenital Heart Disease, Bristol Royal Hospital for Children, Bristol BS2 8BJ, UKPulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this treatment, and its success in treating PAH has led to its widespread uptake in adult and paediatric pulmonary hypertension (PH), as a first line treatment choice. This might apply to persistent pulmonary hypertension of the newborn (PPHN) or bronchopulmonary dysplasia, as well as to more complex diseases, such as idiopathic pulmonary hypertension. Although recent data regarding long-term mortality and the repeal of Food and Drug Administration (FDA) approval has complicated the issue, Sildenafil continues to be the major treatment option for paediatric PH for patients in a variety of contexts, and this does not seem likely to change in the foreseeable future. In this review, we provide a summary of pulmonary hypertension in infants and children and the use of Sildenafil for such diseases.https://www.mdpi.com/2227-9067/4/7/60pulmonary hypertensionSildenafilphosphodiesterase inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Larisa Simonca Robert Tulloh |
spellingShingle |
Larisa Simonca Robert Tulloh Sildenafil in Infants and Children Children pulmonary hypertension Sildenafil phosphodiesterase inhibitor |
author_facet |
Larisa Simonca Robert Tulloh |
author_sort |
Larisa Simonca |
title |
Sildenafil in Infants and Children |
title_short |
Sildenafil in Infants and Children |
title_full |
Sildenafil in Infants and Children |
title_fullStr |
Sildenafil in Infants and Children |
title_full_unstemmed |
Sildenafil in Infants and Children |
title_sort |
sildenafil in infants and children |
publisher |
MDPI AG |
series |
Children |
issn |
2227-9067 |
publishDate |
2017-07-01 |
description |
Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this treatment, and its success in treating PAH has led to its widespread uptake in adult and paediatric pulmonary hypertension (PH), as a first line treatment choice. This might apply to persistent pulmonary hypertension of the newborn (PPHN) or bronchopulmonary dysplasia, as well as to more complex diseases, such as idiopathic pulmonary hypertension. Although recent data regarding long-term mortality and the repeal of Food and Drug Administration (FDA) approval has complicated the issue, Sildenafil continues to be the major treatment option for paediatric PH for patients in a variety of contexts, and this does not seem likely to change in the foreseeable future. In this review, we provide a summary of pulmonary hypertension in infants and children and the use of Sildenafil for such diseases. |
topic |
pulmonary hypertension Sildenafil phosphodiesterase inhibitor |
url |
https://www.mdpi.com/2227-9067/4/7/60 |
work_keys_str_mv |
AT larisasimonca sildenafilininfantsandchildren AT roberttulloh sildenafilininfantsandchildren |
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