Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer.
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family, whereas calcium acts through the calcium sensin...
Main Authors: | Daniel David Bikle, Yan Jiang, Thai Nguyen, Yuko Oda, Chia-ling Tu |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-07-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00296/full |
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