Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features
The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarci...
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Online Access: | http://dx.doi.org/10.1155/2017/1204082 |
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doaj-89ecf6eaec4e4a0d94f66548cd5bd6a02020-11-24T21:02:56ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/12040821204082Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular FeaturesShirui Chen0Kai Zhou1Liguang Yang2Guohui Ding3Hong Li4Shanghai High School, Shanghai 200231, ChinaChildren’s Hospital of Nanjing Medical University, Nanjing 211166, ChinaKey Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaKey Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaKey Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, ChinaThe incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer.http://dx.doi.org/10.1155/2017/1204082 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shirui Chen Kai Zhou Liguang Yang Guohui Ding Hong Li |
spellingShingle |
Shirui Chen Kai Zhou Liguang Yang Guohui Ding Hong Li Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features BioMed Research International |
author_facet |
Shirui Chen Kai Zhou Liguang Yang Guohui Ding Hong Li |
author_sort |
Shirui Chen |
title |
Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features |
title_short |
Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features |
title_full |
Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features |
title_fullStr |
Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features |
title_full_unstemmed |
Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features |
title_sort |
racial differences in esophageal squamous cell carcinoma: incidence and molecular features |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer. |
url |
http://dx.doi.org/10.1155/2017/1204082 |
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