Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist...
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doaj-89eeef4fcfe6491da05908b19e9803a42020-11-25T00:59:57ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-02-011523088311710.3390/ijms15023088ijms15023088Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial AreaStefano Sivolella0Giulia Brunello1Nadia Ferrarese2Alessandro Della Puppa3Domenico D'Avella4Eriberto Bressan5Barbara Zavan6Department of Neurosciences, Institute of Clinical Dentistry,University of Padova, Via Venezia, 90, 35129 Padova, ItalyDepartment of Neurosciences, Institute of Clinical Dentistry,University of Padova, Via Venezia, 90, 35129 Padova, ItalyDepartment of Neurosciences, Institute of Clinical Dentistry,University of Padova, Via Venezia, 90, 35129 Padova, ItalyDepartment of Neurosciences, University of Padua, via Giustiniani, 5, 35128 Padua, ItalyDepartment of Neurosciences, University of Padua, via Giustiniani, 5, 35128 Padua, ItalyDepartment of Neurosciences, Institute of Clinical Dentistry,University of Padova, Via Venezia, 90, 35129 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, Via G. Colombo 3, 35100 Padova, ItalyInjury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments.http://www.mdpi.com/1422-0067/15/2/3088nanofiberscaffoldnerve regenerationelectrospinningself-assemblySAPNS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefano Sivolella Giulia Brunello Nadia Ferrarese Alessandro Della Puppa Domenico D'Avella Eriberto Bressan Barbara Zavan |
spellingShingle |
Stefano Sivolella Giulia Brunello Nadia Ferrarese Alessandro Della Puppa Domenico D'Avella Eriberto Bressan Barbara Zavan Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area International Journal of Molecular Sciences nanofiber scaffold nerve regeneration electrospinning self-assembly SAPNS |
author_facet |
Stefano Sivolella Giulia Brunello Nadia Ferrarese Alessandro Della Puppa Domenico D'Avella Eriberto Bressan Barbara Zavan |
author_sort |
Stefano Sivolella |
title |
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area |
title_short |
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area |
title_full |
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area |
title_fullStr |
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area |
title_full_unstemmed |
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area |
title_sort |
nanostructured guidance for peripheral nerve injuries: a review with a perspective in the oral and maxillofacial area |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-02-01 |
description |
Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments. |
topic |
nanofiber scaffold nerve regeneration electrospinning self-assembly SAPNS |
url |
http://www.mdpi.com/1422-0067/15/2/3088 |
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