A possible role of GDNF expression by which cabergoline use affects corpus callosum
A variety of malformations have been associated with cabergoline use during gestation. Recently we had a preterm male infant referred to our Neonatal Intensive Care Unit diagnosed with corpus callosum agenesis confirmed by brain ultrasound and brain magnetic resonance imaging. The mother was on medi...
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Hygeia Press di Corridori Marinella
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doaj-89efc9417f594b6ebc901451340dda242020-11-25T02:43:11ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922018-12-0181e080112e08011210.7363/080112599A possible role of GDNF expression by which cabergoline use affects corpus callosumGeorgios Mitsiakos0Anastasia Gkampeta12nd Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University, Papageorgiou General Hospital, Thessaloniki, GreeceA variety of malformations have been associated with cabergoline use during gestation. Recently we had a preterm male infant referred to our Neonatal Intensive Care Unit diagnosed with corpus callosum agenesis confirmed by brain ultrasound and brain magnetic resonance imaging. The mother was on medication with cabergoline, due to a pituitary prolactinoma, only for the first month of pregnancy. The exact possible mechanism by witch cabergoline may have a negative effect on corpus callosum development is still unknown. Discovery of neurotrophic brain factors has opened a new chapter in the understanding of neurogenesis and synaptic plasticity mechanisms. To our knowledge, this is the first suggestion of a possible role of glial cell line-derived neurotrophic factor (GDNF) expression on corpus callosum agenesis after the administration of cabergoline in women during pregnancy.https://www.jpnim.com/index.php/jpnim/article/view/708corpus callosumagenesiscabergolinegdnf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Georgios Mitsiakos Anastasia Gkampeta |
spellingShingle |
Georgios Mitsiakos Anastasia Gkampeta A possible role of GDNF expression by which cabergoline use affects corpus callosum Journal of Pediatric and Neonatal Individualized Medicine corpus callosum agenesis cabergoline gdnf |
author_facet |
Georgios Mitsiakos Anastasia Gkampeta |
author_sort |
Georgios Mitsiakos |
title |
A possible role of GDNF expression by which cabergoline use affects corpus callosum |
title_short |
A possible role of GDNF expression by which cabergoline use affects corpus callosum |
title_full |
A possible role of GDNF expression by which cabergoline use affects corpus callosum |
title_fullStr |
A possible role of GDNF expression by which cabergoline use affects corpus callosum |
title_full_unstemmed |
A possible role of GDNF expression by which cabergoline use affects corpus callosum |
title_sort |
possible role of gdnf expression by which cabergoline use affects corpus callosum |
publisher |
Hygeia Press di Corridori Marinella |
series |
Journal of Pediatric and Neonatal Individualized Medicine |
issn |
2281-0692 |
publishDate |
2018-12-01 |
description |
A variety of malformations have been associated with cabergoline use during gestation. Recently we had a preterm male infant referred to our Neonatal Intensive Care Unit diagnosed with corpus callosum agenesis confirmed by brain ultrasound and brain magnetic resonance imaging. The mother was on medication with cabergoline, due to a pituitary prolactinoma, only for the first month of pregnancy. The exact possible mechanism by witch cabergoline may have a negative effect on corpus callosum development is still unknown. Discovery of neurotrophic brain factors has opened a new chapter in the understanding of neurogenesis and synaptic plasticity mechanisms. To our knowledge, this is the first suggestion of a possible role of glial cell line-derived neurotrophic factor (GDNF) expression on corpus callosum agenesis after the administration of cabergoline in women during pregnancy. |
topic |
corpus callosum agenesis cabergoline gdnf |
url |
https://www.jpnim.com/index.php/jpnim/article/view/708 |
work_keys_str_mv |
AT georgiosmitsiakos apossibleroleofgdnfexpressionbywhichcabergolineuseaffectscorpuscallosum AT anastasiagkampeta apossibleroleofgdnfexpressionbywhichcabergolineuseaffectscorpuscallosum AT georgiosmitsiakos possibleroleofgdnfexpressionbywhichcabergolineuseaffectscorpuscallosum AT anastasiagkampeta possibleroleofgdnfexpressionbywhichcabergolineuseaffectscorpuscallosum |
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1724770979286089728 |